Salles Juliette, Lin Rixing, Turecki Gustavo
McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey.
Biol Psychiatry Glob Open Sci. 2024 Nov 10;5(2):100415. doi: 10.1016/j.bpsgos.2024.100415. eCollection 2025 Mar.
Noncoding RNAs comprise most of the transcriptome and represent an emerging area of research. Among them, small nucleolar RNAs (snoRNAs) have emerged as a promising target because they have been associated with the development and evolution of several diseases, including psychiatric disorders. snoRNAs are expressed in the brain, with some showing brain-specific expression that indicates specific roles in brain development, function, and dysfunction. However, the role of snoRNAs in conditions that affect the brain needs further investigation to be better understood. This scoping review summarizes existing literature on studies that have investigated snoRNAs in psychiatry and offers insight into potential pathophysiological mechanisms to be further investigated in future research.
非编码RNA构成了转录组的大部分，是一个新兴的研究领域。其中，小核仁RNA（snoRNA）已成为一个有前景的靶点，因为它们与包括精神疾病在内的多种疾病的发生发展和演变有关。snoRNA在大脑中表达，有些表现出大脑特异性表达，表明其在大脑发育、功能及功能障碍中具有特定作用。然而，snoRNA在影响大脑的疾病中的作用仍需进一步研究以加深理解。本综述总结了精神病学领域中研究snoRNA的现有文献，并深入探讨了潜在的病理生理机制，以供未来研究进一步探究。
