Nobuhara M, Kanamori T, Harada Y, Horisawa Y, Ishii K, Yanagihara Y, Kiyonaga J
Gan To Kagaku Ryoho. 1986 Jan;13(1):134-8.
The effects of human lymphoblastoid interferon-alpha (MOR-22) on the growth of xenografted human tumors in nude mice were examined. IFN-alpha was administered subcutaneously to mice with renal tumor (ACHN), intratumorally for glioblastoma (U-373MG) or intravenously with uterine cervical tumor (HeLa S3). The dosages of IFN-alpha were 2 X 10(4)-5 X 10(5) IU/mouse for ACHN tumor, 1 X 10(5)-5 X 10(5) IU/mouse for U-373MG tumor and 3 X 10(4)-1 X 10(5) IU/mouse for HeLa S3 tumor. IFN-alpha inhibited the growth of these tumors in a dose-dependent manner.
研究了人淋巴母细胞样α干扰素（MOR-22）对裸鼠体内异种移植人肿瘤生长的影响。将α干扰素皮下注射给患有肾肿瘤（ACHN）的小鼠，瘤内注射给胶质母细胞瘤（U-373MG），或静脉注射给子宫颈肿瘤（HeLa S3）。对于ACHN肿瘤，α干扰素的剂量为2×10⁴ - 5×10⁵ IU/小鼠；对于U-373MG肿瘤，剂量为1×10⁵ - 5×10⁵ IU/小鼠；对于HeLa S3肿瘤，剂量为3×10⁴ - 1×10⁵ IU/小鼠。α干扰素以剂量依赖性方式抑制这些肿瘤的生长。
