[β-干扰素的基础研究：第四部分。对裸鼠移植人肿瘤的抗肿瘤作用]
[Basic study on interferon-beta: Part IV. Antitumor effect on nude mouse-transplanted human tumors].
作者信息
Nobuhara M, Kanamori T, Ashida Y, Horisawa Y, Harada Y, Asami T
出版信息
Gan To Kagaku Ryoho. 1986 Jun;13(6):2117-22.
The effects of human interferon-beta (IFN-beta, MR-21) on the growth of xenografted human tumors in nude mice were examined. IFN-beta was administered to mice with malignant melanoma (SK-MEL-28 and Sk-14) intratumorally at a dose of 1 X 10(5)-3 X 10(5) IU/mouse, with acute leukemia (CCRF-HSB-2) intratumorally at a dose of 3 X 10(5) IU/mouse, with glioblastoma (U-373 MG) intravenously or intratumorally at a dose of 1 X 10(5)-6 X 10(5) IU/mouse, or with uterine cervical tumor (HeLa S3) intravenously at a dose of 0.3 X 10(5)-1 X 10(5) IU/mouse. IFN-beta inhibited the growth of all of these tumors in a dose-dependent manner.
研究了人β干扰素（IFN-β，MR-21）对裸鼠体内异种移植人肿瘤生长的影响。将IFN-β以1×10⁵ - 3×10⁵ IU/小鼠的剂量瘤内注射给患有恶性黑色素瘤（SK-MEL-28和Sk-14）的小鼠，以3×10⁵ IU/小鼠的剂量瘤内注射给患有急性白血病（CCRF-HSB-2）的小鼠，以1×10⁵ - 6×10⁵ IU/小鼠的剂量静脉内或瘤内注射给患有胶质母细胞瘤（U-373 MG）的小鼠，或以0.3×10⁵ - 1×10⁵ IU/小鼠的剂量静脉内注射给患有子宫颈肿瘤（HeLa S3）的小鼠。IFN-β以剂量依赖性方式抑制所有这些肿瘤的生长。
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