Karpatkin M, Mannuccio Mannucci P, Bhogal M, Vigano S, Nardi M
Br J Haematol. 1986 Jan;62(1):137-42. doi: 10.1111/j.1365-2141.1986.tb02909.x.
Protein C was measured by electroimmunoassay in 47 infants within 24 h of delivery. Gestational age ranged from 28 to 43 weeks. The mean level was 27% (range less than 10-67%) of the normal adult mean. In the 22 infants who had no clinical problems, protein C levels correlated significantly with gestational age. In the 25 who were sick there was no correlation, and the mean level was significantly lower than that of the healthy infants. Postnatal rise was slow; on day 7 the mean was 32% and on day 28, 31%. Levels of protein C correlated significantly with prothrombin in both the healthy and sick infants. Crossed immunoelectrophoresis in the presence of calcium ions gave one protein C peak of the same electrophoretic mobility as is seen in plasma of healthy adults, indicating that the infants' protein C is gamma carboxylated. It is concluded that: (1) Protein C in neonates is in or below the range associated with thromboembolism in patients congenitally deficient in this protein; (2) protein C levels correlate with gestational age; and (3) the low levels during the neonatal period are not due to decreased gamma carboxylation but may reflect decreased synthesis when compared to the older child or the adult.
在47例婴儿出生后24小时内通过电免疫测定法检测蛋白C。胎龄为28至43周。平均水平为正常成人平均水平的27%（范围为低于10% - 67%）。在22例无临床问题的婴儿中，蛋白C水平与胎龄显著相关。在25例患病婴儿中则无相关性，且平均水平显著低于健康婴儿。出生后蛋白C水平上升缓慢；第7天时平均为32%，第28天时为31%。在健康和患病婴儿中，蛋白C水平与凝血酶原均显著相关。在钙离子存在下进行交叉免疫电泳，出现了一个与健康成人血浆中所见具有相同电泳迁移率的蛋白C峰，表明婴儿的蛋白C是γ羧化的。得出以下结论：（1）新生儿的蛋白C处于或低于先天性缺乏该蛋白的患者中与血栓栓塞相关的范围；（2）蛋白C水平与胎龄相关；（3）新生儿期的低水平并非由于γ羧化减少，而是与大龄儿童或成人相比可能反映了合成减少。
