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新生儿蛋白C缺乏所致肾静脉血栓形成及对治疗的反应

Renal vein thrombosis and response to therapy in a newborn due to protein C deficiency.

作者信息

Rogers P C, Silva M P, Carter J E, Wadsworth L D

机构信息

Department of Paediatrics, BC Children's Hospital, Vancouver, Canada.

出版信息

Eur J Pediatr. 1989 Nov;149(2):124-5. doi: 10.1007/BF01995862.

DOI:10.1007/BF01995862
PMID:2591404
Abstract

A newborn infant was diagnosed as having renal vein thrombosis due to heterozygous protein C deficiency and no other predisposing factor for thrombosis. He responded adequately to treatment with streptokinase, fresh frozen plasma and subsequent anticoagulation with heparin and warfarin (Coumadin). Four years from diagnosis he remains well with no recurrence of thrombosis and with normal renal function.

摘要

一名新生儿因杂合子蛋白C缺乏且无其他血栓形成易感因素而被诊断为肾静脉血栓形成。他对链激酶、新鲜冷冻血浆治疗以及随后使用肝素和华法林(香豆素)进行抗凝治疗反应良好。自诊断以来四年,他情况良好,血栓未复发,肾功能正常。

相似文献

1
Renal vein thrombosis and response to therapy in a newborn due to protein C deficiency.新生儿蛋白C缺乏所致肾静脉血栓形成及对治疗的反应
Eur J Pediatr. 1989 Nov;149(2):124-5. doi: 10.1007/BF01995862.
2
Partial renal vein thrombosis in a kidney transplant: management by streptokinase and heparin.肾移植中部分肾静脉血栓形成:链激酶与肝素治疗
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3
Heterozygous protein C deficiency presenting as severe protein C deficiency and peripartum thrombosis: successful treatment with protein C concentrate.表现为严重蛋白C缺乏和围产期血栓形成的杂合子蛋白C缺乏症:蛋白C浓缩物治疗成功。
Obstet Gynecol. 1995 Oct;86(4 Pt 2):662-4. doi: 10.1016/0029-7844(95)00039-t.
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[Massive inferior vena cava thrombosis associated with protein C deficiency. Clinical case].[与蛋白C缺乏相关的下腔静脉巨大血栓形成。临床病例]
Rev Med Chil. 1997 Apr;125(4):451-6.
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Streptokinase salvage of renal function after renal vein thrombosis.肾静脉血栓形成后链激酶对肾功能的挽救作用
Ann Intern Med. 1984 Feb;100(2):237-8. doi: 10.7326/0003-4819-100-2-237.
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Am J Pediatr Hematol Oncol. 1994 May;16(2):127-31.
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Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden).一名患有因子V突变(FV莱顿突变)的新生儿出现双侧肾静脉血栓形成和静脉窦血栓形成。
J Pediatr. 1998 Jan;132(1):159-61. doi: 10.1016/s0022-3476(98)70504-9.
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[Neonatal venous thrombosis and familial protein C deficiency. A difficult diagnosis].[新生儿静脉血栓形成与家族性蛋白C缺乏症。一项困难的诊断]
Ann Pediatr (Paris). 1989 May;36(5):343-4.
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[Results of treatment of acute renal vein thrombosis with streptokinase].[链激酶治疗急性肾静脉血栓形成的结果]
Pediatr Pol. 1983 Dec;58(12):989-93.
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[Congenital deficiency and molecular abnormality of protein C].[蛋白C先天性缺乏与分子异常]
Rinsho Byori. 1987 May;35(5):511-3.

引用本文的文献

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Thrombosis in the critically ill neonate: incidence, diagnosis, and management.危重新生儿的血栓形成:发病率、诊断与管理
Vasc Health Risk Manag. 2008;4(6):1337-48. doi: 10.2147/vhrm.s4274.
2
Hemostatic complications in renal disorders of the young.青少年肾脏疾病中的止血并发症。
Pediatr Nephrol. 1996 Feb;10(1):88-99. doi: 10.1007/BF00863459.

本文引用的文献

1
Congenital protein C deficiency and venous thromboembolism. A study of three Dutch families.先天性蛋白C缺乏与静脉血栓栓塞。对三个荷兰家庭的研究。
N Engl J Med. 1983 Aug 11;309(6):340-4. doi: 10.1056/NEJM198308113090604.
2
Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn.
N Engl J Med. 1984 Mar 1;310(9):559-62. doi: 10.1056/NEJM198403013100904.
3
Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex.使用凝血酶-血栓调节蛋白复合物测定抗血栓蛋白C的功能水平。
Blood. 1984 Jan;63(1):15-21.
4
Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant.一名新生儿的遗传性蛋白C缺乏症与香豆素反应性慢性复发性暴发性紫癜
Lancet. 1983 Nov 19;2(8360):1165-8. doi: 10.1016/s0140-6736(83)91216-3.
5
Deficiencies of protein C, an inhibitor of blood coagulation.
Lancet. 1982 Aug 28;2(8296):463-7. doi: 10.1016/s0140-6736(82)90494-9.
6
Low-dose fibrinolytic therapy in infants.婴儿的低剂量纤维蛋白溶解疗法。
J Pediatr. 1985 Apr;106(4):594-8. doi: 10.1016/s0022-3476(85)80078-0.
7
Prothrombin and protein C in early childhood: normal adult levels are not achieved until the fourth year of life.幼儿期的凝血酶原和蛋白C:直到4岁时才能达到正常成人水平。
J Pediatr. 1986 Nov;109(5):843-5. doi: 10.1016/s0022-3476(86)80708-9.
8
Purpura fulminans in a Chinese boy with congenital protein C deficiency.一名患有先天性蛋白C缺乏症的中国男孩出现暴发性紫癜。
Pediatrics. 1986 May;77(5):670-6.
9
Low protein C in the neonatal period.新生儿期蛋白C水平低。
Br J Haematol. 1986 Jan;62(1):137-42. doi: 10.1111/j.1365-2141.1986.tb02909.x.
10
Absence of thrombosis in subjects with heterozygous protein C deficiency.杂合子蛋白C缺乏症患者无血栓形成。
N Engl J Med. 1987 Oct 15;317(16):991-6. doi: 10.1056/NEJM198710153171604.