Zhang Jianyi, Liu Lang, Ning Xunan, Lin Meiqing, Lai Xiaojun
School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China; Institute of Environmental Health and Pollution Control, Guangdong-Hong Kong-Macao Joint Laboratory for Pollutant Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou 510006, China.
School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China; Institute of Environmental Health and Pollution Control, Guangdong-Hong Kong-Macao Joint Laboratory for Pollutant Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou 510006, China.
Sci Total Environ. 2023 Nov 25;901:165982. doi: 10.1016/j.scitotenv.2023.165982. Epub 2023 Aug 2.
Nonylphenols (NPs) are crucial fine chemicals widely employed in producing industrial and consumer surfactants that ultimately enter the environment through various pathways, leading to environmental pollution. NPs are suspected endocrine-disrupting chemicals that may accumulate in the body over time, resulting in unusual reproductive function. Due to limitations in analytical methods, NPs have typically been quantified as a whole in some studies. However, NPs are a mixture of multibranched structures, and different NP isomers exhibit distinct environmental behaviors and toxic effects. Therefore, it is critical to analyze environmental and human biological samples at the isomer-specific level to elucidate the contamination characteristics, human exposure load, and toxic effects of NPs. Accurately analyzing NP samples with various isomers, metabolites, and transformation products presents a significant challenge. This review summarizes recent advances in analytical research on NPs in technical products, environmental, and human biological samples, particularly emphasizing the synthesis and separation of standards and the transformation of NP homolog isomers in samples. Finally, the review highlights the research gaps and future research directions in this domain.
壬基酚（NPs）是重要的精细化学品，广泛应用于工业和消费品表面活性剂的生产中，这些表面活性剂最终通过各种途径进入环境，导致环境污染。壬基酚被怀疑是内分泌干扰化学物质，可能会随着时间的推移在体内蓄积，导致生殖功能异常。由于分析方法的局限性，在一些研究中，壬基酚通常被整体定量。然而，壬基酚是多支链结构的混合物，不同的壬基酚异构体表现出不同的环境行为和毒性效应。因此，在异构体特异性水平上分析环境和人类生物样本，以阐明壬基酚的污染特征、人体暴露负荷和毒性效应至关重要。准确分析含有各种异构体、代谢物和转化产物的壬基酚样品是一项重大挑战。本文综述了技术产品、环境和人类生物样本中壬基酚分析研究的最新进展，特别强调了标准品的合成与分离以及样品中壬基酚同系物异构体的转化。最后，本文突出了该领域的研究差距和未来研究方向。
