Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.
Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.
Clin Perinatol. 2023 Sep;50(3):669-681. doi: 10.1016/j.clp.2023.04.014. Epub 2023 Jun 20.
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants. Severe anemia and red blood cell (RBC) transfusion are associated with gut inflammation and injury in preclinical models and observational studies. However, there is uncertainty about the causal role of these factors in the pathogenesis of NEC. Observational studies have shown that withholding feeding during RBC transfusion may reduce the risk of NEC, although confirmatory data from randomized trials are lacking. In this review, we summarize data on feeding during RBC transfusion and its role in NEC and highlight ongoing randomized trials.
新生儿坏死性小肠结肠炎（NEC）是早产儿发病和死亡的主要原因。在临床前模型和观察性研究中，严重贫血和红细胞（RBC）输血与肠道炎症和损伤有关。然而，这些因素在 NEC 的发病机制中的因果作用尚不确定。观察性研究表明，在输血过程中暂停喂养可能会降低 NEC 的风险，尽管缺乏来自随机试验的确认性数据。在这篇综述中，我们总结了 RBC 输血期间喂养的相关数据及其在 NEC 中的作用，并强调了正在进行的随机试验。
