University of Cincinnati College of Medicine, Department of Surgery, Division of Transplantation, 231 Albert Sabin Way, Medical Science Building Room 1555, Cincinnati, OH 45267-0558.
University of Cincinnati College of Medicine, Department of Surgery, Division of Transplantation, 231 Albert Sabin Way, Medical Science Building Room 1555, Cincinnati, OH 45267-0558.
Adv Surg. 2023 Sep;57(1):171-185. doi: 10.1016/j.yasu.2023.04.001. Epub 2023 May 16.
Colorectal cancer with liver metastases is a condition with significant morbidity and mortality that affects many people around the world. Many treatments exist to target liver metastases, including surgical resection, chemotherapy, nonsurgical liver-directed therapies, and liver transplantation. The field of transplant oncology is emerging as a promising alternative to palliative chemotherapy alone in appropriately selected patients. Though few clinical trials have been completed to evaluate safety of liver transplant for colorectal cancer metastases, there are several ongoing trials to hopefully make transplant a viable option for more patients with limited options.
结直肠癌伴肝转移是一种发病率和死亡率都很高的疾病，影响着全世界许多人。有许多治疗方法可以针对肝转移，包括手术切除、化疗、非手术肝脏定向治疗和肝移植。移植肿瘤学领域正在成为一种有前途的替代方法，与单独姑息性化疗相比，在适当选择的患者中具有优势。尽管已经完成了少数临床试验来评估肝移植治疗结直肠癌转移的安全性，但仍有一些正在进行的试验，希望使移植成为更多选择有限的患者的可行选择。
