肠道在伤口感染中的作用是什么？
What Is the Role of the Gut in Wound Infections?
机构信息
Department of Surgery, University of Chicago, Pritzker School of Medicine, 5841 South Maryland, Chicago, IL 60637, USA.
University of Nevada, Reno School of Medicine, 1664 North Virginia Street, Reno, NV 89557, USA.
出版信息
Adv Surg. 2023 Sep;57(1):31-46. doi: 10.1016/j.yasu.2023.05.002. Epub 2023 Jun 25.
Abstract
Emerging evidence suggest a major role for the gut microbiome in wound infections. A Trojan Horse mechanism of surgical site infections has been hypothesized to occur when pathogens in the gut, gums, and periodontal areas enter an immune cell and silently travel to the wound site where they release their infectious payload. Genetic tracking of microbes at the strain level is now possible with genetic sequencing techniques and can clarify the origin of microbes that cause wound infections. An emerging field of dietary prehabilitation to modulate the microbiome before surgery is being described to improve infection-related outcomes from surgery.
摘要
新出现的证据表明，肠道微生物组在伤口感染中起着重要作用。有人假设，当肠道、牙龈和牙周区域的病原体进入免疫细胞并悄悄转移到伤口部位时，就会发生手术部位感染的特洛伊木马机制，在那里它们释放出传染性的有效载荷。随着基因测序技术的发展，现在可以对微生物进行菌株水平的基因跟踪，并可以阐明导致伤口感染的微生物的来源。目前正在描述一种新的饮食前适应领域，即在手术前调节微生物组，以改善与感染相关的手术结果。
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