Department of Pathology, New York University Grossman School of Medicine, NYU Langone Health, 560 First Avenue TH-483, New York, NY 10016, USA.
Department of Pathology, Yale School of Medicine, Yale New Haven Hospital, 20 York Street EP2-611, New Haven, CT 06510, USA.
Surg Pathol Clin. 2023 Sep;16(3):565-580. doi: 10.1016/j.path.2023.04.010. Epub 2023 May 31.
Hepatic inflammatory pseudotumor (IPT) describes a mass lesion composed of fibroblasts or myofibroblasts with a dense inflammatory infiltrate comprising lymphocyte, plasma cells, and histiocytes. These lesions are presumed to be an exuberant response to an infectious organism, although in most cases the causative agent is unknown. In specific circumstances, pathologists should consider ancillary techniques to exclude specific infections, such as mycobacteria, Candida, or syphilis. IgG4-related disease may cause a plasma-cell rich IPT. Finally, true neoplasms can mimic IPTs and must be excluded with appropriate ancillary studies, including inflammatory myofibroblastic tumor, follicular dendritic cell tumor, inflammatory angiomyolipoma, Hodgkin lymphoma, and inflammatory hepatocellular carcinoma.
肝炎性假瘤（IPT）描述了一种由成纤维细胞或肌纤维母细胞组成的肿块病变，伴有密集的炎症浸润，包括淋巴细胞、浆细胞和组织细胞。这些病变被认为是对感染病原体的过度反应，尽管在大多数情况下，病原体是未知的。在特定情况下，病理学家应考虑辅助技术来排除特定的感染，如分枝杆菌、念珠菌或梅毒。IgG4 相关疾病可引起富含浆细胞的 IPT。最后，真正的肿瘤可以模仿 IPT，必须通过适当的辅助研究排除，包括炎性肌纤维母细胞瘤、滤泡树突细胞肿瘤、炎性血管平滑肌脂肪瘤、霍奇金淋巴瘤和炎性肝细胞癌。
