Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, Box 0102, San Francisco, CA 94143, USA.
Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, Box 0102, San Francisco, CA 94143, USA.
Surg Pathol Clin. 2023 Sep;16(3):581-598. doi: 10.1016/j.path.2023.04.011. Epub 2023 Jun 9.
Needle core biopsies of liver lesions can be challenging, particularly in cases with limited material. The differential diagnosis for well-differentiated hepatocellular lesions includes focal nodular hyperplasia, hepatocellular adenoma, and well-differentiated hepatocellular carcinoma (HCC) in noncirrhotic liver, while dysplastic nodules and well-differentiated HCC are the primary considerations in cirrhotic liver. The first part of this review focuses on histochemical and immunohistochemical stains as well as molecular assays that are useful in the differential diagnosis. The second portion describes the features of hepatocellular adenoma subtypes and focuses on the differential diagnoses in commonly encountered clinicopathologic scenarios.
肝脏病变的针芯活检具有挑战性，尤其是在标本有限的情况下。在非肝硬化肝脏中，分化良好的肝细胞病变的鉴别诊断包括局灶性结节性增生、肝细胞腺瘤和分化良好的肝细胞癌（HCC），而在肝硬化肝脏中，发育不良结节和分化良好的 HCC 是主要考虑因素。本综述的第一部分重点介绍了在鉴别诊断中有用的组织化学和免疫组织化学染色以及分子检测方法。第二部分描述了肝细胞腺瘤亚型的特征，并重点介绍了常见临床病理情况下的鉴别诊断。
