Choi Joon Hyuk
Department of Pathology, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Republic of Korea.
Int J Mol Sci. 2025 Aug 10;26(16):7729. doi: 10.3390/ijms26167729.
Liver biopsy remains an indispensable diagnostic modality in contemporary hepatology because most classification systems and pathogenetic concepts are grounded in morphology. The diagnostic yield of a biopsy hinges on specimen adequacy and meticulous tissue processing; however, interpretation often challenges even experienced pathologists. This narrative review summarizes practical aspects of histological and molecular assessment for both clinicians and pathologists. Key topics include specimen handling, selection of ancillary stains, recognition of pivotal patterns of hepatic injury, and a systematic approach to differential diagnosis. Mastery of both histological and molecular principles is essential for accurate diagnosis, appropriate therapy, and reliable prognostication.
肝活检在当代肝病学中仍然是一种不可或缺的诊断方式，因为大多数分类系统和发病机制概念都基于形态学。活检的诊断成功率取决于标本的充分性和细致的组织处理；然而，即使是经验丰富的病理学家，解读也常常具有挑战性。这篇叙述性综述总结了临床医生和病理学家在组织学和分子评估方面的实际要点。关键主题包括标本处理、辅助染色的选择、肝损伤关键模式的识别以及鉴别诊断的系统方法。掌握组织学和分子原理对于准确诊断、恰当治疗和可靠预后至关重要。
