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Cancer Causes Control. 2023 Mar;34(3):251-265. doi: 10.1007/s10552-022-01660-0. Epub 2022 Dec 15.
2
Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration.终生暴露于香烟烟雾与 T 细胞肿瘤免疫浸润所致卵巢癌风险的关系。
Cancer Epidemiol Biomarkers Prev. 2023 Jan 9;32(1):66-73. doi: 10.1158/1055-9965.EPI-22-0877.
3
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CA Cancer J Clin. 2022 Jan;72(1):7-33. doi: 10.3322/caac.21708. Epub 2022 Jan 12.
4
High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.高预诊炎症相关风险评分与卵巢癌生存降低相关。
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5
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8
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炎症相关暴露与黑人女性多中心队列研究中卵巢癌生存的关联。

Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women.

机构信息

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.

Department of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia, SC, USA.

出版信息

Br J Cancer. 2023 Oct;129(7):1119-1125. doi: 10.1038/s41416-023-02385-w. Epub 2023 Aug 3.

DOI:10.1038/s41416-023-02385-w
PMID:37537254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539498/
Abstract

BACKGROUND

An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival.

METHODS

The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DII), were evaluated.

RESULTS

A dose-response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01-1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02-1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16-2.06).

CONCLUSION

Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women.

摘要

背景

在一项以白人女性为主的侵袭性上皮性卵巢癌（EOC）患者队列中，炎症相关风险评分（IRRS）与总生存（OS）较差之间存在关联。在此，我们评估了 IRRS 与黑人女性 EOC 患者 OS 之间的关联，黑人女性存在更高频率的促炎暴露和更差的生存。

方法

该分析纳入了来自非裔美国人癌症流行病学研究（AACES）的 592 名黑人女性，这些女性被诊断为患有 EOC。使用 Cox 比例风险模型计算了 IRRS 与 OS 之间的风险比（HR）和 95%置信区间（CI），并调整了相关协变量。评估了其他炎症相关暴露因素，包括能量调整的饮食炎症指数（E-DII）。

结果

观察到剂量反应趋势，表明较高的 IRRS 与较差的 OS 相关（每四分位 HR：1.11，95%CI：1.01-1.22）。在模型中加入 E-DII 后，IRRS 与 OS 的关联减弱，而 E-DII 的增加，表明饮食更具促炎作用，与较短的 OS 相关（每四分位 HR：1.12，95%CI：1.02-1.24）。两个指数评分较高与较短的 OS 相关（HR：1.54，95%CI：1.16-2.06）。

结论

炎症相关暴露水平较高与黑人女性 EOC 患者 OS 降低相关。