白细胞介素-5 水平与疟疾严重程度的关系：系统评价。

Interleukin-5 levels in relation to malaria severity: a systematic review.

机构信息

Medical Technology Program, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Malar J. 2023 Aug 3;22(1):226. doi: 10.1186/s12936-023-04659-3.

DOI:10.1186/s12936-023-04659-3

PMID:37537570

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10401852/

Abstract

BACKGROUND

The role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to synthesize variations in IL-5 levels between severe and uncomplicated malaria, as well as between malaria and controls not afflicted with the disease.

METHODS

This systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022368773). Searches for studies that reported IL-5 levels in patients with malaria (any severity) and/or uninfected individuals were performed in Web of Science, PubMed, EMBASE, Scopus, CENTRAL, and MEDLINE, between 1st and 10th October, 2022. The risk of bias among all included studies was minimized using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational studies. The differences in IL-5 levels between malaria and uninfected controls, and between severe and uncomplicated malaria were synthesized by narrative synthesis.

RESULTS

Among 1177 articles identified in the databases, 23 matched the eligibility criteria and were included in this systematic review. Qualitative syntheses showed the heterogeneity of IL-5 levels between different severities of clinical malaria and uninfected controls. The majority of the included studies (12/15 studies, 80%) found no change in IL-5 levels between malaria cases and uninfected controls. Similarly, most studies found no difference in IL-5 levels between severe (regardless of complications) and uncomplicated malaria (4/8 studies, 50%). The qualitative syntheses revealed that most studies found no difference in IL-5 levels between severe and non-severe malaria.

CONCLUSIONS

The comprehensive review suggests that IL-5 levels are unchanged in patients with different levels of clinical severity of malaria and uninfected controls. Given the limited number of published studies on IL-5 levels in malaria, there is a need for additional research to determine the function of this cytokine in the pathogenesis of malaria.

摘要

背景

细胞因子（如白细胞介素 5 [IL-5]）在疟疾发病机制中的作用仍不清楚。本系统评价旨在综合严重疟疾和无并发症疟疾以及疟疾和未患该病的对照者之间的 IL-5 水平差异。

方法

本系统评价在国际前瞻性登记系统评价（PROSPERO；CRD42022368773）中进行。于 2022 年 10 月 1 日至 10 日，在 Web of Science、PubMed、EMBASE、Scopus、CENTRAL 和 MEDLINE 中检索报道疟疾（任何严重程度）患者和/或未感染者 IL-5 水平的研究。使用报告观察性研究的加强观察性研究报告（STROBE）指南，将所有纳入研究的偏倚风险降至最低。通过叙述性综合方法综合疟疾与未感染者对照者之间以及严重疟疾与无并发症疟疾之间的 IL-5 水平差异。

结果

在数据库中识别的 1177 篇文章中，有 23 篇符合入选标准并纳入本系统评价。定性综合结果显示，不同严重程度临床疟疾患者与未感染者对照者之间的 IL-5 水平存在异质性。大多数纳入研究（12/15 项研究，80%）发现疟疾患者与未感染者对照者之间的 IL-5 水平没有变化。同样，大多数研究发现严重（无论有无并发症）和无并发症疟疾患者的 IL-5 水平没有差异（4/8 项研究，50%）。定性综合结果显示，大多数研究发现严重和非严重疟疾患者的 IL-5 水平没有差异。