Fang Zhen, Li Peijuan, Du Fengying, Shang Liang, Li Leping
Department of Gastroenterological Surgery, Shandong Provincial Hospital of Shandong First Medical University, Jingwuweiqi street, 324, Jinan, 250021, Shandong, China.
Department of Digestive Tumour Translational Medicine, Engineering Laboratory of Shandong Province, Shandong Provincial Hospital, Jinan, 250021, Shandong, China.
Exp Hematol Oncol. 2023 Aug 3;12(1):69. doi: 10.1186/s40164-023-00433-y.
Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo. Organoids have attracted much attention in recent years. They can provide a reliable technology platform for cancer research and treatment and are a valuable preclinical model for academic research and personalized medicine. A number of studies have confirmed that organoids have great application prospects in new drug development, drug screening, tumour mechanism research, and precision medicine. In this review, we mainly focus on recent advances in the application of organoids in cancer research. We also discussed the opportunities and challenges facing organoids, hoping to indicate directions for the development of organoids in the future.
类器官是通过体外三维培养建立的，它们可以模拟体内器官或组织的结构和生理功能。近年来，类器官备受关注。它们可为癌症研究和治疗提供可靠的技术平台，是学术研究和个性化医疗中一种有价值的临床前模型。多项研究证实，类器官在新药研发、药物筛选、肿瘤机制研究和精准医学方面具有广阔的应用前景。在本综述中，我们主要关注类器官在癌症研究应用方面的最新进展。我们还讨论了类器官面临的机遇和挑战，希望为类器官未来的发展指明方向。
