Li Zhengwei, Li Kai, Zhang Cheng, Zhao Yingying, Guo Yiyuan, He Jia, Chang Shiyuan, Fang Xinyi, Liu Kaizheng, Zhu Pingping, Chen Zhenzhen, Ruan Changshun
State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, School of Life Sciences, Zhengzhou University, Henan, 450001, China.
Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou, 450001, China.
Adv Sci (Weinh). 2025 Sep;12(33):e07317. doi: 10.1002/advs.202507317. Epub 2025 Jul 25.
Bioprinted organoids integrate bioprinting technology with organoid research, enabling the simultaneous reconstruction of human tissue morphology and physiological function in vitro. This approach offers distinct advantages in organoid fabrication, particularly in terms of structural precision, tissue mimicry, and functional fidelity. By leveraging the complementary strengths of both technologies, bioprinted organoids allow for the fabrication of personalized, architecturally engineered models that more accurately replicate organogenesis, physiological processes, and disease progression. Herein, this review outlines the key advantages of bioprinted organoids, with a focus on their ability to precisely control morphology, dimensions, and spatial organization. Bioprinted organoids are further categorized into three types based on their cellular origins and summarize recent progress in their application for human tissue modeling. Finally, ongoing challenges and future possibilities are sketched out, offering insights for potential innovation and research directions in the field. Bioprinted organoids not only propel the advancement of organoid research but also drive the evolution of bioprinting technologies. This integrated approach represents a powerful synergy between biomanufacturing and clinical medicine to pave the way for a new era in biomedical science and personalized healthcare.
生物打印类器官将生物打印技术与类器官研究相结合，能够在体外同时重建人体组织形态和生理功能。这种方法在类器官制造方面具有显著优势，特别是在结构精度、组织模拟和功能保真度方面。通过利用这两种技术的互补优势，生物打印类器官能够制造出个性化的、经过结构设计的模型，更准确地复制器官发生、生理过程和疾病进展。在此，本综述概述了生物打印类器官的关键优势，重点关注其精确控制形态、尺寸和空间组织的能力。生物打印类器官根据其细胞来源进一步分为三种类型，并总结了它们在人体组织建模应用中的最新进展。最后，勾勒出当前面临的挑战和未来的可能性，为该领域的潜在创新和研究方向提供见解。生物打印类器官不仅推动了类器官研究的发展，也推动了生物打印技术的演变。这种综合方法代表了生物制造与临床医学之间的强大协同作用，为生物医学科学和个性化医疗的新时代铺平了道路。
