División Ciencias de la Salud, Universidad del Norte Barranquilla, Barranquilla, Colombia.
Facultad de Ciencias de la Salud, Programa de Medicina, Universidad Libre Seccional Barranquilla, Barranquilla, Colombia.
Mol Microbiol. 2023 Sep;120(3):341-350. doi: 10.1111/mmi.15133. Epub 2023 Aug 3.
Respiratory syncytial virus (RSV) is a virus that causes acute respiratory infections in neonates and older adults. To infect host cells, the attachment glycoprotein (G) interacts with a cell surface receptor. This interaction determines the specific cell types that are susceptible to infection. RSV possesses a type I fusion protein F. Type I fusion proteins are metastable when rearrangement of the prefusion F occurs; the fusion peptide is exposed transforming the protein into postfusion form. The transition between the prefusion form and its postfusion form facilitates the viral envelope and the host cell membrane to fuse, enabling the virus to enter the host cell. Understanding the entry mechanism employed by RSV is crucial for developing effective antiviral therapies. In this review, we will discuss the various types of viral fusion proteins and explore the potential entry mechanisms utilized by RSV. A deeper understanding of these mechanisms will provide valuable insights for the development of novel approaches to treat RSV infections.
呼吸道合胞病毒（RSV）是一种导致新生儿和老年人急性呼吸道感染的病毒。为了感染宿主细胞，附着糖蛋白（G）与细胞表面受体相互作用。这种相互作用决定了易感染的特定细胞类型。RSV 具有 I 型融合蛋白 F。当发生预融合 F 的重排时，I 型融合蛋白是亚稳定的；融合肽暴露，将蛋白质转化为融合后形式。预融合形式和融合后形式之间的转变促进了病毒包膜和宿主细胞膜的融合，使病毒能够进入宿主细胞。了解 RSV 采用的进入机制对于开发有效的抗病毒疗法至关重要。在这篇综述中，我们将讨论各种类型的病毒融合蛋白，并探讨 RSV 可能采用的进入机制。深入了解这些机制将为开发治疗 RSV 感染的新方法提供有价值的见解。
