Semwal Bhupesh Chander, Singh Bhoopendra, Murti Yogesh, Singh Sonia
Institute of Pharmaceutical Research GLA University, Mathura U.P. 281406, India.
B.S.A College of Engineering and Technology Mathura U.P. 281004, India.
Curr Pharm Biotechnol. 2023 Aug 4. doi: 10.2174/1389201024666230804102617.
Ascorbic acid is a potent natural antioxidant that protects against oxidative stress and performs various bodily functions. It is commonly found in fruits and vegetables.
The manuscript has been written to provide valuable insights into ascorbic acid in managing Alzheimer's disease.
The data has been gathered from web sources, including PubMed, Science Direct, Publons, Web of Science, and Scopus from 2000-2022 using AA, ascorbic acid, Alzheimer's diseases, memory, dementia, and antioxidant Keywords.
In the present manuscript, we have summarized the impact of ascorbic acid and its possible mechanism in Alzheimer's disease by, outlining the information currently available on the behavioral and biochemical effects of ascorbic acid in animal models of Alzheimer's disease as well as its usage as a therapeutic agent to slow down the progression of Alzheimer disease in human beings. Oxidative stress plays a significant role in the advancement of AD. AA is a wellknown antioxidant that primarily reduces oxidative stress and produces protein aggregates, which may help decrease cognitive deficits in Alzheimer's disease. The current paper analyses of ascorbic acid revealed that deficiency of ascorbic acid adversely affects the central nervous system and leads to cognitive defects. However, the results of clinical studies are conflicting, but some of the studies suggested that supplementation of ascorbic acid improved cognitive deficits and decreased disease progression.
Based on clinical and preclinical studies, it is observed that ascorbic acid supplementation improves cognitive deficits and protects the neurons from oxidative stress injury.
抗坏血酸是一种强大的天然抗氧化剂，可抵御氧化应激并执行多种身体功能。它常见于水果和蔬菜中。
撰写本文是为了深入探讨抗坏血酸在治疗阿尔茨海默病方面的作用。
使用抗坏血酸、维生素C、阿尔茨海默病、记忆、痴呆和抗氧化剂等关键词，从2000年至2022年的网络资源中收集数据，包括PubMed、Science Direct、Publons、Web of Science和Scopus。
在本论文中，我们总结了抗坏血酸的影响及其在阿尔茨海默病中的可能机制，概述了目前关于抗坏血酸在阿尔茨海默病动物模型中的行为和生化作用的信息，以及其作为治疗剂用于减缓人类阿尔茨海默病进展的情况。氧化应激在阿尔茨海默病的发展中起重要作用。抗坏血酸是一种著名的抗氧化剂，主要减少氧化应激并产生蛋白质聚集体，这可能有助于减少阿尔茨海默病中的认知缺陷。本文对抗坏血酸的分析表明，抗坏血酸缺乏会对中枢神经系统产生不利影响并导致认知缺陷。然而，临床研究结果相互矛盾，但一些研究表明补充抗坏血酸可改善认知缺陷并减缓疾病进展。
基于临床和临床前研究，观察到补充抗坏血酸可改善认知缺陷并保护神经元免受氧化应激损伤。
