Jama Ishak Abdi, Usman Ibe Michael, Oviosun Augustine, Eze Ejike Daniel, Adeniyi Ismahil Adekunle, Etukudo Ekom Monday, Kwizera Eliah, Owembabazi Elna, Anyanwu Emeka
Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Department of Physiology, School of Medicine, Kabale University, Kabale, Uganda.
J Exp Pharmacol. 2025 Jun 27;17:403-416. doi: 10.2147/JEP.S522973. eCollection 2025.
The use of medicine plants in the management of various human ailments have gained lots of attention in recent time; hence, the present study aimed to investigate the impact of on the behavioral, oxidative stress and cerebellar cortical histoarchitectural alterations during bisphenol A exposure in mice.
Thirty (30) adult male mice were divided into six groups. Group 1 received distilled water (2 mls/kg b.w). and group 2 was treated with (bisphenol A) BPA (100 mg/kg body weight). Groups 3-5 were co-treated with varying doses of (250 mg/kg, 500 mg/kg, and 1000 mg/kg b.w). and group 6 received vitamin C (60 mg/kg b.w). along with BPA. The animals underwent neurobehavioral tests (beam walking and wire hang). Other parameters evaluated included body weight, oxidative stress biomarkers, and cerebellar histology.
Animals treated with high doses of spent less time crossing the beam during the beam walking test and more time in the wire hang test than those treated with BPA alone. Lowered malondialdehyde level and higher catalase and superoxide dismutase activity was observed in treated groups than in the BPA-only group. Histological examination revealed a significant improvement in the cerebellar tissue structure in treated groups, particularly at higher doses.
demonstrated potential protective effects against BPA-induced oxidative stress and negative histological changes in the cerebellar cortex, suggesting its therapeutic potential for mitigating BPA neurotoxicity. Further research is needed to explore the therapeutic applicability.
近年来，药用植物在治疗各种人类疾病方面的应用受到了广泛关注；因此，本研究旨在探讨[具体药物名称未给出]对双酚A暴露小鼠行为、氧化应激和小脑皮质组织架构改变的影响。
将30只成年雄性小鼠分为六组。第1组给予蒸馏水（2毫升/千克体重）。第2组用双酚A（BPA，100毫克/千克体重）处理。第3 - 5组分别用不同剂量的[具体药物名称未给出]（250毫克/千克、500毫克/千克和1000毫克/千克体重）进行联合处理。第6组在给予BPA的同时给予维生素C（60毫克/千克体重）。对动物进行神经行为测试（走横梁和悬线试验）。评估的其他参数包括体重、氧化应激生物标志物和小脑组织学。
与仅用BPA处理的动物相比，用高剂量[具体药物名称未给出]处理的动物在走横梁测试中穿过横梁的时间更短，在悬线试验中停留的时间更长。与仅用BPA处理的组相比，[具体药物名称未给出]处理组的丙二醛水平降低，过氧化氢酶和超氧化物歧化酶活性升高。组织学检查显示，[具体药物名称未给出]处理组，特别是高剂量组的小脑组织结构有显著改善。
[具体药物名称未给出]对BPA诱导的氧化应激和小脑皮质的负面组织学变化显示出潜在的保护作用，表明其在减轻BPA神经毒性方面的治疗潜力。需要进一步研究以探索其治疗适用性。
