Assessment of the Impact of on Behavioral, Oxidative Stress and Cerebellar Cortical Histoarchitectural Alterations During Bisphenol A Exposure in Mice.

PURPOSE

The use of medicine plants in the management of various human ailments have gained lots of attention in recent time; hence, the present study aimed to investigate the impact of on the behavioral, oxidative stress and cerebellar cortical histoarchitectural alterations during bisphenol A exposure in mice.

METHODS

Thirty (30) adult male mice were divided into six groups. Group 1 received distilled water (2 mls/kg b.w). and group 2 was treated with (bisphenol A) BPA (100 mg/kg body weight). Groups 3-5 were co-treated with varying doses of (250 mg/kg, 500 mg/kg, and 1000 mg/kg b.w). and group 6 received vitamin C (60 mg/kg b.w). along with BPA. The animals underwent neurobehavioral tests (beam walking and wire hang). Other parameters evaluated included body weight, oxidative stress biomarkers, and cerebellar histology.

RESULTS

Animals treated with high doses of spent less time crossing the beam during the beam walking test and more time in the wire hang test than those treated with BPA alone. Lowered malondialdehyde level and higher catalase and superoxide dismutase activity was observed in treated groups than in the BPA-only group. Histological examination revealed a significant improvement in the cerebellar tissue structure in treated groups, particularly at higher doses.

CONCLUSION

demonstrated potential protective effects against BPA-induced oxidative stress and negative histological changes in the cerebellar cortex, suggesting its therapeutic potential for mitigating BPA neurotoxicity. Further research is needed to explore the therapeutic applicability.