一种包含DNA螺旋畸变规则的序列分析系统。
A sequence analysis system encompassing rules for DNA helical distortion.
作者信息
Shapiro B A, Nussinov R, Lipkin L E, Maizel J V
出版信息
Nucleic Acids Res. 1986 Jan 10;14(1):75-86. doi: 10.1093/nar/14.1.75.
Recently, it has been shown by Calladine (1982) and Dickerson (1983) that DNA distortions due to steric clashes between opposing purines and pyrimidines can be quantitated based upon four sum functions. The distortions involve helical twist, roll, torsion angle variations and propeller twist. It is the contention of the authors that these perturbations in structure act as information carriers for various external DNA interactions. This paper describes a system that incorporates these four rules and various other functions that permit the systematic interactive exploration for significant patterns as a consequence of these steric clashes.
最近，卡拉丹（1982年）和迪克森（1983年）指出，由于相对的嘌呤和嘧啶之间的空间冲突而导致的DNA扭曲可以基于四个总和函数进行定量。这些扭曲包括螺旋扭转、滚动、扭转角变化和螺旋桨扭转。作者认为，这些结构上的扰动充当了各种外部DNA相互作用的信息载体。本文描述了一个系统，该系统纳入了这四条规则以及各种其他函数，这些函数允许对由于这些空间冲突而产生的显著模式进行系统的交互式探索。
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