用于揭示B-DNA双螺旋三维总体结构对一级结构依赖性的计算机图形程序。
Computer graphics program to reveal the dependence of the gross three-dimensional structure of the B-DNA double helix on primary structure.
作者信息
Tung C S, Harvey S C
出版信息
Nucleic Acids Res. 1986 Jan 10;14(1):381-7. doi: 10.1093/nar/14.1.381.
Abstract
Programs are presented to plot the gross three-dimensional structure of the DNA double helix with the base sequence as input information. The rules that determine the overall structure of the double helix are those that predict the dependence of local helix parameters (specifically, helix twist angle and relative basepair roll angle) on sequence. For this purpose, the user can select either the Calladine-Dickerson parameters or the Tung-Harvey parameters. These programs can be used as tools to investigate the variation of DNA tertiary structure with sequence, which may play an important role in the sequence-specific recognition of DNA by proteins.
摘要
提供了一些程序，用于根据碱基序列作为输入信息来绘制DNA双螺旋的总体三维结构。决定双螺旋整体结构的规则是那些预测局部螺旋参数（具体而言，螺旋扭转角和相对碱基对滚动角）对序列的依赖性的规则。为此，用户可以选择卡拉迪恩 - 迪克森参数或董 - 哈维参数。这些程序可用作研究DNA三级结构随序列变化的工具，这可能在蛋白质对DNA的序列特异性识别中起重要作用。
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