Gao Yuan, Wu Xiaoxia, Zhao Ning, Bai Dong
Fang Zheng Center, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.
Front Pharmacol. 2023 Jul 19;14:1152858. doi: 10.3389/fphar.2023.1152858. eCollection 2023.
Revealing the connotation of the compatibility of Chinese medicines (CM) is a requirement for the modernization of traditional Chinese medicine (TCM). However, no consensus exists on the specific mechanism of traditional Chinese medicine compatibility (TCMC). Many studies have shown that the occurrence and development of diseases and the efficacy of CM are closely related to intestinal flora (IF), which may provide a new perspective to understand the theory of TCM. This study aimed to summarize the relationship between the changes in IF before and after the compatibility of different drugs and the synergistic, toxicity reduction, and incompatibility effects of drug pairs from the perspective of the effects of CM on the IF and the regulation of microbial metabolites. These studies showed that the effect of drug pairs on the composition of the IF is not a simple superposition of two single drugs, and that the drug pairs also play a specific role in regulating the production of intestinal bacterial metabolites; therefore, it has a different pharmacodynamic effect, which may provide a perspective to clarify the compatibility mechanism. However, research on the interpretation of the scientific connotations of TCMC from the perspective of the IF is still in its infancy and has limitations. Therefore, this study aimed to summarize previous research experience and proposed to conduct a deep and systematic study from the perspective of drug pair dismantling, IF, intestinal bacteria metabolite, organism, and disease to provide a reference for scientific research on the compatibility mechanism of CM.
揭示中药配伍的内涵是中医药现代化的要求。然而，对于中药配伍的具体机制尚无共识。许多研究表明，疾病的发生发展以及中药的疗效与肠道菌群密切相关，这可能为理解中医理论提供新的视角。本研究旨在从中药对肠道菌群的影响以及微生物代谢产物的调节角度，总结不同药物配伍前后肠道菌群变化与药对协同、减毒及相反作用之间的关系。这些研究表明，药对对肠道菌群组成的影响并非两种单一药物的简单叠加，药对在调节肠道细菌代谢产物的产生方面也发挥着特定作用；因此，其具有不同的药效学作用，这可能为阐明配伍机制提供一个视角。然而，从肠道菌群角度阐释中药配伍科学内涵的研究仍处于起步阶段且存在局限性。因此，本研究旨在总结以往研究经验，提出从药对拆方、肠道菌群、肠道细菌代谢产物、机体及疾病等角度进行深入系统研究，为中药配伍机制的科研工作提供参考。
