Mai Lan-Yin, Li Yi-Xuan, Chen Yong, Xie Zhen, Li Jie, Zhong Ming-Yu
Zhongguo Zhong Yao Za Zhi. 2014 May;39(10):1749-56.
The compatibility of traditional Chinese medicines (TCMs) formulae containing enormous information, is a complex component system. Applications of mathematical statistics methods on the compatibility researches of traditional Chinese medicines formulae have great significance for promoting the modernization of traditional Chinese medicines and improving clinical efficacies and optimizations of formulae. As a tool for quantitative analysis, data inference and exploring inherent rules of substances, the mathematical statistics method can be used to reveal the working mechanisms of the compatibility of traditional Chinese medicines formulae in qualitatively and quantitatively. By reviewing studies based on the applications of mathematical statistics methods, this paper were summarized from perspective of dosages optimization, efficacies and changes of chemical components as well as the rules of incompatibility and contraindication of formulae, will provide the references for further studying and revealing the working mechanisms and the connotations of traditional Chinese medicines.
中药复方蕴含着巨大的信息，是一个复杂的成分体系。数学统计方法在中药复方配伍研究中的应用，对于推动中药现代化、提高临床疗效和优化方剂具有重要意义。作为一种定量分析、数据推断和探索物质内在规律的工具，数学统计方法可用于定性和定量地揭示中药复方配伍的作用机制。通过回顾基于数学统计方法应用的研究，本文从剂量优化、药效及化学成分变化以及方剂配伍禁忌和用药禁忌规则等方面进行总结，将为进一步研究和揭示中药的作用机制及内涵提供参考。
