Allakany Ahmed I, Elbanna Amany A, Rohoma Kamel H, Ahmed Shwikar M, Ibrahim Ahmed E, Fawzy Moamen A, Header Doaa A
Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Prz Gastroenterol. 2023;18(2):190-197. doi: 10.5114/pg.2023.126055. Epub 2023 Mar 22.
Type 1 diabetes mellitus (T1DM) is an autoimmune disease. The gut microbiota has been proposed as a key actor in the pathogenesis of T1DM.
To identify the gut microbiome that are likely to be related to T1DM. This may have an impact on the future understanding of the pathogenesis of T1DM and possible approaches to prevent and treat it.
The study included 40 T1DM patients and a cross-matching control group of 20 healthy subjects of matched age and sex; stool specimens were taken from each group. Quantitative SYBR Green Real-Time PCR technique targeting 16S rRNA was done for the identification and quantitation of , and .
T1DM patients showed significantly higher ( < 0.001) and ( = 0.003), but lower ( = 0.013) than the control group. However, there was no statistical difference between T1DM and control cases as regards ( = 0.204), ( = 0.598), ( = 0.901), and ( = 0.332).
Egyptian patients showed dysbiosis of the gut microbiome that can be related to the pathogenesis of T1DM. This hopefully points to the potential therapeutic benefits of manipulating the composition of the gut microbiome in the management of, or even protection from, T1DM.
1型糖尿病（T1DM）是一种自身免疫性疾病。肠道微生物群被认为是T1DM发病机制中的关键因素。
识别可能与T1DM相关的肠道微生物组。这可能会对未来对T1DM发病机制的理解以及预防和治疗T1DM的可能方法产生影响。
该研究纳入了40例T1DM患者以及一个年龄和性别匹配的20名健康受试者的交叉匹配对照组；从每组采集粪便样本。采用针对16S rRNA的定量SYBR Green实时荧光定量PCR技术对[具体微生物名称未给出]进行鉴定和定量。
与对照组相比，T1DM患者的[具体微生物名称未给出]显著更高（<0.001）和[具体微生物名称未给出]更高（=0.003），但[具体微生物名称未给出]更低（=0.013）。然而，在[具体微生物名称未给出]（=0.204）、[具体微生物名称未给出]（=0.598）、[具体微生物名称未给出]（=0.901）和[具体微生物名称未给出]（=0.332）方面，T1DM患者与对照组之间无统计学差异。
埃及患者表现出肠道微生物组的生态失调，这可能与T1DM的发病机制有关。这有望指出在T1DM的管理甚至预防中操纵肠道微生物组组成的潜在治疗益处。
