Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.
Front Endocrinol (Lausanne). 2020 Mar 24;11:125. doi: 10.3389/fendo.2020.00125. eCollection 2020.
Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D.
1 型糖尿病（T1D）是一种由遗传、表观遗传和环境因素介导的多因素自身免疫性疾病。近年来，高通量测序的出现使我们能够研究肠道微生物群在 T1D 发展中的作用。在有临床或临床前 T1D 的患者中，肠道微生物组的组成发生了显著变化，也称为失调。然而，这种失调是疾病的原因还是结果尚不清楚。目前，越来越多的证据支持肠道微生物群与 T1D 发展之间存在因果关系。本综述将重点关注肠道微生物组与 T1D 进展之间关联的最新研究，旨在评估其因果关系。我们还将讨论肠道微生物群失衡导致 T1D 发展的可能机制。
