National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing, China.
Front Endocrinol (Lausanne). 2023 Jul 17;14:1173933. doi: 10.3389/fendo.2023.1173933. eCollection 2023.
Diabetic nephropathy (DN) is one of the most common complications of diabetes, and its main manifestations are progressive proteinuria and abnormal renal function, which eventually develops end stage renal disease (ESRD). The pathogenesis of DN is complex and involves many signaling pathways and molecules, including metabolic disorders, genetic factors, oxidative stress, inflammation, and microcirculatory abnormalities strategies. With the development of medical experimental techniques, such as single-cell transcriptome sequencing and single-cell proteomics, the pathological alterations caused by kidney cell interactions have attracted more and more attention. Here, we reviewed the characteristics and related mechanisms of crosstalk among kidney cells podocytes, endothelial cells, mesangial cells, pericytes, and immune cells during the development and progression of DN and highlighted its potential therapeutic effects.
糖尿病肾病（DN）是糖尿病最常见的并发症之一，其主要表现为进行性蛋白尿和肾功能异常，最终发展为终末期肾病（ESRD）。DN 的发病机制复杂，涉及多种信号通路和分子，包括代谢紊乱、遗传因素、氧化应激、炎症和微循环异常等。随着医学实验技术的发展，如单细胞转录组测序和单细胞蛋白质组学，肾脏细胞相互作用引起的病理改变越来越受到关注。在这里，我们综述了在 DN 的发生和发展过程中，足细胞、内皮细胞、系膜细胞、周细胞和免疫细胞之间相互作用的特征和相关机制，并强调了其潜在的治疗效果。
