Lindpaintner K, Lindpaintner L S, Wentworth M, Burns C P
Cancer. 1986 Apr 1;57(7):1284-6. doi: 10.1002/1097-0142(19860401)57:7<1284::aid-cncr2820570705>3.0.co;2-#.
The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease. In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.
作者报告了一例局灶性心肌坏死病例,该病例临床上表现为在一名无冠状动脉疾病的患者使用抗肿瘤药物安吖啶期间发生急性心肌梗死。除了已公认的心律失常并发症外,作者强调心肌坏死可能是安吖啶相关心脏毒性的进一步表现。