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促性腺激素释放激素的垂体外作用：直接抑制卵巢类固醇生成。

Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis.

作者信息

Hsueh A J, Erickson G F

出版信息

Science. 1979 May 25;204(4395):854-5. doi: 10.1126/science.375393.

DOI:10.1126/science.375393
PMID:375393
Abstract

Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.

摘要

促性腺激素释放激素（GnRH）及其激动剂类似物在体外抑制了大鼠卵巢颗粒细胞中促卵泡激素（FSH）诱导的雌激素和孕酮生成增加。同样，GnRH类似物在体内抑制了垂体切除大鼠中FSH诱导的卵巢功能变化。这些结果表明，GnRH除了在垂体中具有众所周知的促性腺激素释放作用外，还对卵巢类固醇生成发挥直接抑制作用。

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Science. 1979 May 25;204(4395):854-5. doi: 10.1126/science.375393.
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