Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, 3819693345, Iran.
Department of Nursing, Khomein University of Medical Sciences, Khomein, 3881743364, Iran.
Future Cardiol. 2023 Jun;19(7):375-381. doi: 10.2217/fca-2022-0130. Epub 2023 Aug 4.
Hypertrophic cardiomyopathy (HCM) is a rare and heterogeneous disorder in newborns, which can predispose them to other cardiac conditions such as myocardial infarction (MI). This case report describes the clinical presentation of a premature infant born at 30 weeks of gestation, who developed cardiac failure due to myocardial ischemia. The newborn exhibited distal acrocyanosis and respiratory distress shortly after birth. Echocardiography revealed significant left ventricular hypercontractility and hypertrophy, along with moderate pericardial effusion, tricuspid regurgitation and mitral regurgitation. Despite treatment with furosemide and inotropes, the patient's condition deteriorated, leading to demise after 14 days. Early detection of MI in newborns with vascular complications and HCM plays a crucial role in their management. In conclusion, the coexistence of acute MI and hypertrophic cardiomyopathy may be indicative of a fatal outcome. Hypertrophic cardiomyopathy (HCM) is a rare and heterogeneous disorder in newborns, which can predispose them to other cardiac conditions such as MI. This case report describes the clinical presentation of a premature infant born at 30 weeks of gestation, who developed cardiac failure due to myocardial ischemia. The newborn exhibited distal acrocyanosis and respiratory distress after birth. Echocardiography revealed significant left ventricular hypercontractility, moderate pericardial effusion, tricuspid regurgitation and mitral regurgitation. Despite treatment, the patient's condition deteriorated, leading to demise after 14 days. Early detection of MI in newborns with vascular complications and HCM plays a crucial role in their management. In conclusion, the coexistence of acute MI and hypertrophic cardiomyopathy may be indicative of a fatal outcome.
肥厚型心肌病（HCM）是一种罕见且异质性的新生儿疾病，可使他们易患其他心脏疾病，如心肌梗死（MI）。本病例报告描述了一名胎龄 30 周的早产儿的临床表现，他因心肌缺血而发生心力衰竭。新生儿出生后出现远侧肢端发绀和呼吸窘迫。超声心动图显示左心室明显收缩过度和肥厚，伴有中度心包积液、三尖瓣反流和二尖瓣反流。尽管使用呋塞米和正性肌力药进行治疗，但患者病情恶化，14 天后死亡。对于伴有血管并发症和 HCM 的新生儿，早期发现 MI 对于其治疗至关重要。总之，急性 MI 和肥厚型心肌病的共存可能预示着致命结局。
