Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Clinical Laboratory, Yunnan Center for Disease Control and Prevention, Kunming, China.
Nat Prod Res. 2024 Jun;38(12):2060-2068. doi: 10.1080/14786419.2023.2241968. Epub 2023 Aug 4.
was extensively used to control blood sugar in diabetes treatment in tradition Chinese medicine. In the present study, three new compounds, including an iridoid rehmannia A () and two ionone rehmannias B-C (), together with fourteen known compounds (- and -), were isolated from the roots of . The structures of these compounds were determined by physicochemical constants and spectral analysis (1D, 2D-NMR and MS). The effect of on -glucosidase activity was tested . Compounds , , and (IC: 5.0, 3.1, and 6.3 mM) showed moderate activity to suppress -glucosidase relative to acarbose (IC = 3.0 mM). The findings provided some new insights to understand the hypoglycemic effect of and the development towards the -glucosidase inhibitor drugs.
在传统中药中，地黄被广泛用于控制糖尿病患者的血糖。本研究从地黄的根部分离得到了三个新化合物，包括一个环烯醚萜类化合物地黄 A（）和两个薁酮类化合物地黄 B-C（），以及另外 14 个已知化合物（-和-）。这些化合物的结构通过理化常数和光谱分析（1D、2D-NMR 和 MS）确定。测试了地黄对 -葡萄糖苷酶活性的影响。化合物 、 、和 （IC：5.0、3.1 和 6.3 mM）对 -葡萄糖苷酶的抑制活性与阿卡波糖（IC = 3.0 mM）相比具有中等活性。这些发现为理解地黄的降血糖作用以及开发 -葡萄糖苷酶抑制剂药物提供了一些新的见解。
