Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Nat Prod Res. 2024 Jul;38(14):2505-2510. doi: 10.1080/14786419.2023.2187796. Epub 2023 Mar 8.
One new iridoid namely rupesin F () together with four known ones (-) were isolated from the roots of Jones. The structures were established using spectroscopic methods (1D and 2D NMR including HSQC, HMBC, COSY and NOESY) and by comparison with previously published literature data. The isolated compounds and exhibited strong α-glucosidase inhibition activity with IC values of 10.13 ± 0.11 and 9.13 ± 0.03 μg/mL, respectively. This study enriched the chemical diversity of metabolites and provides a direction for the development of antidiabetic agents.
从Jones 的根部分离得到一个新的环烯醚萜类化合物，即鲁斯因 F（），以及四个已知的化合物（-）。结构通过光谱方法（包括 HSQC、HMBC、COSY 和 NOESY 的 1D 和 2D NMR）和与以前发表的文献数据进行比较来确定。分离得到的化合物和 表现出强烈的α-葡萄糖苷酶抑制活性，IC 值分别为 10.13±0.11 和 9.13±0.03 μg/mL。本研究丰富了代谢产物的化学多样性，为开发抗糖尿病药物提供了方向。
