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一种水溶性荧光有机纳米光敏剂,可用于具有光动力治疗潜力的线粒体 G-四链体的比率检测。

A water-soluble fluorescent organic nano-photosensitizer for the ratiometric detection of mitochondrial G-quadruplexes with photodynamic therapy potential.

机构信息

College of Chemistry, Beijing Normal University, Beijing, 100875, China.

Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing, 100875, China.

出版信息

Chem Commun (Camb). 2023 Aug 22;59(68):10287-10290. doi: 10.1039/d3cc02788k.

DOI:10.1039/d3cc02788k
PMID:37539814
Abstract

We report a water-soluble AIEgen (TPAL) that can self-assemble into fluorescent organic nanoparticles for the ratiometric detection of mitochondrial DNA (mtDNA) parallel G-quadruplexes (G4s) with high selectivity, a low detection limit and photodynamic therapy (PDT) potential.

摘要

我们报道了一种水溶性 AIEgen(TPAL),它可以自组装成荧光有机纳米粒子,用于高选择性、低检测限的线粒体 DNA(mtDNA)平行 G-四链体(G4)的比率检测,并且具有光动力治疗(PDT)的潜力。

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Light-Activated Molecules Targeting G-Quadruplex Nucleic Acids.靶向G-四链体核酸的光激活分子
Chemistry. 2025 Jul 11;31(39):e202501545. doi: 10.1002/chem.202501545. Epub 2025 Jun 23.
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Optical Probes for Cellular Imaging of G-quadruplexes: Beyond Fluorescence Intensity Probes.用于G-四链体细胞成像的光学探针:超越荧光强度探针。
Angew Chem Int Ed Engl. 2025 May 26;64(22):e202424931. doi: 10.1002/anie.202424931. Epub 2025 Apr 21.