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A peek at the other side of the coin: Tumor-suppressor role of microRNAs expressed by pancreatic cancer-associated fibroblasts.

作者信息

Tushoski-Alemán Gerik, Davidson Aaron, Herremans Kelly, Forsmark Chris, Zhang Weizhou, Hughes Steven, Han Song

机构信息

Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, USA.

Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.

出版信息

Clin Transl Med. 2023 Aug;13(8):e1357. doi: 10.1002/ctm2.1357.

DOI:10.1002/ctm2.1357
PMID:37539872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10401917/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e3a/10401917/ee4ed8ea35c6/CTM2-13-e1357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e3a/10401917/ee4ed8ea35c6/CTM2-13-e1357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e3a/10401917/ee4ed8ea35c6/CTM2-13-e1357-g001.jpg

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A peek at the other side of the coin: Tumor-suppressor role of microRNAs expressed by pancreatic cancer-associated fibroblasts.审视硬币的另一面：胰腺癌相关成纤维细胞表达的微小RNA的肿瘤抑制作用
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Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma.正常及癌相关成纤维细胞以及胰腺导管腺癌的BxPc3和MIA PaCa-2细胞系中所选微小RNA的表达
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本文引用的文献

1
A Quick Guide to CAF Subtypes in Pancreatic Cancer.胰腺癌中CAF亚型快速指南
Cancers (Basel). 2023 May 4;15(9):2614. doi: 10.3390/cancers15092614.
2
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.单细胞分析定义了支持抗肿瘤免疫的胰腺成纤维细胞谱系。
Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22.
3
Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin.癌症相关成纤维细胞抑制癌症发展：硬币的另一面
Front Cell Dev Biol. 2021 Feb 4;9:613534. doi: 10.3389/fcell.2021.613534. eCollection 2021.
4
Pancreatic cancer microenvironment: a current dilemma.胰腺癌微环境：当前的困境
Clin Transl Med. 2019 Jan 15;8(1):2. doi: 10.1186/s40169-019-0221-1.
5
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.IL1 诱导的 JAK/STAT 信号被 TGFβ拮抗，从而塑造胰腺导管腺癌中 CAF 的异质性。
Cancer Discov. 2019 Feb;9(2):282-301. doi: 10.1158/2159-8290.CD-18-0710. Epub 2018 Oct 26.
6
Stroma-derived extracellular vesicles deliver tumor-suppressive miRNAs to pancreatic cancer cells.基质衍生的细胞外囊泡将肿瘤抑制性miRNA传递给胰腺癌细胞。
Oncotarget. 2017 Dec 20;9(5):5764-5777. doi: 10.18632/oncotarget.23532. eCollection 2018 Jan 19.
7
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.胰腺肿瘤微环境驱动微小RNA（miRNA）表达的变化，这些变化促进细胞因子的产生，并抑制肿瘤相关基质的迁移。
Oncotarget. 2016 Jul 20;8(33):54054-54067. doi: 10.18632/oncotarget.10722. eCollection 2017 Aug 15.
8
TGF-β in pancreatic cancer initiation and progression: two sides of the same coin.转化生长因子-β在胰腺癌起始与进展中的作用：同一硬币的两面
Cell Biosci. 2017 Aug 7;7:39. doi: 10.1186/s13578-017-0168-0. eCollection 2017.
9
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.胰腺癌中不同的炎性成纤维细胞和肌成纤维细胞群体。
J Exp Med. 2017 Mar 6;214(3):579-596. doi: 10.1084/jem.20162024. Epub 2017 Feb 23.
10
OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.致癌miRNA还是肿瘤抑制因子？微小RNA在癌症中的两面性
Cancer Res. 2016 Jul 1;76(13):3666-70. doi: 10.1158/0008-5472.CAN-16-0359. Epub 2016 Jun 20.