Student Research Committee, Tabriz University of Medical, Sciences, Tabriz, Iran.
School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Food Funct. 2023 Aug 14;14(16):7654-7662. doi: 10.1039/d3fo00300k.
: The purpose of this umbrella meta-analysis was to quantitatively summarize meta-analyses of randomized controlled trial (RCT) studies regarding the effects of probiotic supplementation on () eradication. : A thorough search of the electronic databases including PubMed, Web of Science, Embase, Scopus, and Google Scholar was carried out from the inception up to May 2022. For the evaluation of overall effect sizes, the pooled relative risk (RR) or odds ratio (OR) and their corresponding 95% confidence intervals (CI) were calculated. The random-effects model was used for the meta-analysis. : Overall, 18 eligible studies (47 278 participants in total) were included in the study. The findings revealed that probiotics have a beneficial impact on eradication (pooled ES: 1.13; 95% CI: 1.11, 1.14, < 0.01, and ES = 1.86, 95% CI: 1.70, 2.03, < 0.01). Greater effects on eradication were observed when higher doses (>10 × 10 CFU) and mixed strains were supplemented. : The present umbrella meta-analysis suggests that supplementation with probiotics may be considered as an efficient approach to ameliorate complications, particularly probiotics with higher CFUs and mixed strains.
：本伞式荟萃分析的目的是定量总结随机对照试验（RCT）研究中关于益生菌补充对（）根除效果的荟萃分析。：从创建到 2022 年 5 月，我们彻底检索了电子数据库，包括 PubMed、Web of Science、Embase、Scopus 和 Google Scholar。为了评估总体效应大小，计算了汇总相对风险（RR）或优势比（OR）及其相应的 95%置信区间（CI）。荟萃分析采用随机效应模型。：总体而言，有 18 项符合条件的研究（总共 47278 名参与者）纳入了本研究。研究结果表明，益生菌对（）根除具有有益影响（汇总 ES：1.13；95%CI：1.11，1.14， < 0.01，和 ES = 1.86，95%CI：1.70，2.03， < 0.01）。当补充较高剂量（>10×10 CFU）和混合菌株时，对（）根除的效果更大。：本伞式荟萃分析表明，补充益生菌可能被认为是改善（）相关并发症的有效方法，特别是具有更高 CFU 和混合菌株的益生菌。
