Ye Zhi-Ning, Eslick Guy D, Huang Shao-Gang, He Xing-Xiang
The Affiliated Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.
The Australian Paediatric Surveillance Unit, The University of Sydney, The Children's Hospital, Sydney, New South Wale, Australia.
eGastroenterology. 2024 Dec 23;2(4):e100099. doi: 10.1136/egastro-2024-100099. eCollection 2024 Oct.
The sustained increase in antibiotic resistance leads to a declining trend in the eradication rate of () infection with antibiotic-based eradication regimens. Administration of a single probiotic shows limited efficacy in eradicating infection. This review indicates that faecal microbiota transplantation (FMT), a novel therapeutic approach, either as a monotherapy or adjunctive therapy, exhibits beneficial effects in terms of the eradication of infection and the prevention of adverse events. The role of FMT in eradication may be associated directly or indirectly with some therapeutic constituents within the faecal suspension, including bacteria, viruses, antimicrobial peptides and metabolites. In addition, variations in donor selection, faecal suspension preparation and delivery methods are believed to be the main factors determining the effectiveness of FMT for the treatment of infection. Future research should refine the operational procedures of FMT to achieve optimal efficacy for infection and explore the mechanisms by which FMT acts against .
抗生素耐药性的持续增加导致基于抗生素的根除方案对（）感染的根除率呈下降趋势。单一益生菌的施用在根除感染方面显示出有限的疗效。本综述表明，粪便微生物群移植（FMT）作为一种新型治疗方法，无论是作为单一疗法还是辅助疗法，在根除感染和预防不良事件方面均显示出有益效果。FMT在根除方面的作用可能直接或间接与粪便悬液中的一些治疗成分有关，包括细菌、病毒、抗菌肽和代谢产物。此外，供体选择、粪便悬液制备和给药方法的差异被认为是决定FMT治疗感染有效性的主要因素。未来的研究应完善FMT的操作程序，以实现对感染的最佳疗效，并探索FMT对抗的作用机制。
