基于手性螺二芴的大环化合物在碱性水溶液中的合成及主客体化学
Synthesis and Host-Guest Chemistry of Chiral Spirobifluorene-Based Macrocycles Soluble in Basic Aqueous Solution.
作者信息
Nakagawa Kotoko, Akimoto Kanaru, Nakayasu Bunta, Nagashima Saki, Tobisu Mamoru, Schramm Michael P, Aoyagi Shinobu, Amaya Toru
机构信息
Department of Information and Basic Science, Graduate School of Science, Nagoya City University, 1 Yamanohata, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8501, Japan.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2023 Aug 18;25(32):5969-5973. doi: 10.1021/acs.orglett.3c02074. Epub 2023 Aug 4.
Synthesis and host-guest chemistry of water-soluble (pH 12.5) chiral spirobifluorene-based macrocycles were carried out. Cationic guests, such as quaternary ammonium salts, were accommodated well in the hosts. CpCo was especially strongly bound in ( of up to 3.0 × 10 M). Enantioselective recognition with (l)-carnitine was also achieved.
开展了水溶性（pH 12.5）基于手性螺二芴的大环化合物的合成及主客体化学研究。阳离子客体，如季铵盐，能很好地被主体容纳。CpCo在主体中结合尤其强烈（结合常数高达3.0×10⁶ M⁻¹）。对（l）-肉碱也实现了对映选择性识别。
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