Nakagawa Kotoko, Akimoto Kanaru, Nakayasu Bunta, Nagashima Saki, Tobisu Mamoru, Schramm Michael P, Aoyagi Shinobu, Amaya Toru
Department of Information and Basic Science, Graduate School of Science, Nagoya City University, 1 Yamanohata, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8501, Japan.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Org Lett. 2023 Aug 18;25(32):5969-5973. doi: 10.1021/acs.orglett.3c02074. Epub 2023 Aug 4.
Synthesis and host-guest chemistry of water-soluble (pH 12.5) chiral spirobifluorene-based macrocycles were carried out. Cationic guests, such as quaternary ammonium salts, were accommodated well in the hosts. CpCo was especially strongly bound in ( of up to 3.0 × 10 M). Enantioselective recognition with (l)-carnitine was also achieved.
开展了水溶性（pH 12.5）基于手性螺二芴的大环化合物的合成及主客体化学研究。阳离子客体，如季铵盐，能很好地被主体容纳。CpCo在主体中结合尤其强烈（结合常数高达3.0×10⁶ M⁻¹）。对（l）-肉碱也实现了对映选择性识别。
