Schaefer K, Saupe J, Pauls A, von Herrath D
Klin Wochenschr. 1986 Jan 15;64(2):89-91. doi: 10.1007/BF01784135.
A 74-year-old woman was hospitalized because of decreased appetite, fatigue, and weight loss. The laboratory examination revealed hypercalcemia, a slightly increased serum creatinine level, and a markedly elevated serum level of 1,25-dihydroxyvitamin D3. The most important finding the physical examination revealed was enlarged inguinal lymph nodes. A biopsy disclosed lymphocyte-depleted Hodgkin's disease. After steroids, but not after calcitonin, both the elevated calcitriol concentration and serum calcium normalized. In spite of intensive chemotherapy, a further episode with hypercalcemia occurred and increased 1,25-dihydroxyvitamin D3 serum levels were observed. According to the available evidence it seems probable that the humoral hypercalcemia in this patient resulted from production of 1,25-dihydroxyvitamin D3 in the tumor.
一名74岁女性因食欲减退、疲劳和体重减轻入院。实验室检查发现高钙血症、血清肌酐水平略有升高以及血清1,25-二羟维生素D3水平显著升高。体格检查最重要的发现是腹股沟淋巴结肿大。活检显示为淋巴细胞消减型霍奇金病。使用类固醇后，而非降钙素后，升高的骨化三醇浓度和血清钙均恢复正常。尽管进行了强化化疗，仍再次出现高钙血症，且观察到血清1,25-二羟维生素D3水平升高。根据现有证据，该患者的体液性高钙血症可能是由肿瘤产生1,25-二羟维生素D3所致。
