Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Turkey.
Vascular. 2024 Apr;32(2):310-319. doi: 10.1177/17085381231193494. Epub 2023 Aug 4.
Peripheral arterial disease (PAD) results from the systemic atherosclerotic process. In this study, we aimed to determine the relationship between plasma atherogenic index (AIP), a ratio of molar concentrations of triglycerides to HDL-cholesterol, and long-term outcomes after endovascular therapy (EVT) in patients with superficial femoral artery (SFA) stenosis.
We retrospectively evaluated 673 patients who underwent EVT for PAD in our tertiary center between January 2015 and December 2020. In the receiver operating characteristic (ROC) curve analysis, the AIP value with the optimum cutoff value was determined as 0.576 to detect the presence of major adverse limb events (MALEs). Patients were divided into two groups according to low AIP (<0.576 as group 1) and high AIP (>0.576 as group 2).
Among the major endpoints, long-term restenosis rates were significantly higher in patients in the high-AIP group than in the low-AIP group (<.001). The lower extremity amputation rate was not statistically significant between the two groups. All-cause mortality rate (54 (31.6) versus 117 (68.4), <.001) was significantly higher in patients in the high-AIP group than in the low-AIP group. In addition, the MALE rate (94 (29.2) versus 218 (62.1), <.001) was significantly higher in patients in the high-AIP group than in those in the low-AIP group.
In conclusion, we found that AIP is a significant independent predictor of long-term MALE in patients who underwent EVT for SFA.
外周动脉疾病（PAD）是全身性动脉粥样硬化过程的结果。在本研究中，我们旨在确定血浆致动脉粥样硬化指数（AIP）——甘油三酯与高密度脂蛋白胆固醇摩尔浓度之比，与股浅动脉（SFA）狭窄患者血管内治疗（EVT）后长期结局之间的关系。
我们回顾性评估了 2015 年 1 月至 2020 年 12 月期间在我们的三级中心接受 EVT 治疗 PAD 的 673 例患者。在接收者操作特征（ROC）曲线分析中，确定 AIP 值的最佳截断值为 0.576，以检测主要不良肢体事件（MALEs）的存在。根据 AIP 值（<0.576 为组 1，>0.576 为组 2）将患者分为两组。
在主要终点中，高 AIP 组患者的长期再狭窄率明显高于低 AIP 组（<.001）。两组之间下肢截肢率无统计学意义。高 AIP 组患者的全因死亡率（54（31.6）比 117（68.4），<.001）明显高于低 AIP 组。此外，高 AIP 组患者的 MALEs 发生率（94（29.2）比 218（62.1），<.001）明显高于低 AIP 组。
总之，我们发现 AIP 是接受 SFA EVT 治疗的患者发生长期 MALEs 的独立重要预测因素。
