Department of Pharmaceutical Sciences, International University of Health and Welfare, Tochigi 324-8501, Japan.
Structure. 2023 Aug 3;31(8):891-892. doi: 10.1016/j.str.2023.07.003.
In this issue of Structure, Gonzalez et al. present the cryo-EM structure of Karyopherin-β2 bound to the proline-tyrosine nuclear localization signal (PY-NLS) of heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2). The structure advances our understanding of not only the diversity of PY-NLSs but also the pathogenic mechanisms arising from HNRNPH2 variants.
在本期《结构》杂志中，Gonzalez 等人展示了核输入蛋白-β2 与异质核糖核蛋白 H2（HNRNPH2）的脯氨酸-酪氨酸核定位信号（PY-NLS）结合的冷冻电镜结构。该结构不仅增进了我们对 PY-NLS 多样性的理解，也增进了对 HNRNPH2 变体引起的致病机制的理解。
