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用小胶质细胞移植来治疗阿尔茨海默病。

Replacing microglia to treat Alzheimer's disease.

机构信息

Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.

Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.

出版信息

Cell Stem Cell. 2023 Aug 3;30(8):1001-1003. doi: 10.1016/j.stem.2023.07.005.

DOI:10.1016/j.stem.2023.07.005
PMID:37541204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10542828/
Abstract

In this issue of Cell Stem Cell, Yoo et al. report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.

摘要

在本期《Cell Stem Cell》杂志中，Yoo 等人报道称，用源自系统移植造血细胞的 Trem2 野生型小胶质细胞样细胞替代 Trem2 敲除小胶质细胞，可纠正淀粉样变性小鼠模型中小胶质细胞功能障碍。这些发现强调了小胶质细胞替代疗法治疗阿尔茨海默病的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad55/10542828/bfddba54949a/nihms-1932448-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad55/10542828/bfddba54949a/nihms-1932448-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad55/10542828/bfddba54949a/nihms-1932448-f0001.jpg

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本文引用的文献

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Cell Stem Cell. 2023 Aug 3;30(8):1043-1053.e6. doi: 10.1016/j.stem.2023.07.006.
2
Clonal hematopoiesis is associated with protection from Alzheimer's disease.克隆性造血与阿尔茨海默病的保护有关。
Nat Med. 2023 Jul;29(7):1662-1670. doi: 10.1038/s41591-023-02397-2. Epub 2023 Jun 15.
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An in vivo neuroimmune organoid model to study human microglia phenotypes.体内神经免疫类器官模型用于研究人类小胶质细胞表型。
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Alzheimers Res Ther. 2024 Oct 16;16(1):229. doi: 10.1186/s13195-024-01583-9.
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Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice.小胶质细胞再定植限制了小鼠的眼内炎症和脉络膜新生血管。
Front Immunol. 2024 Apr 22;15:1366841. doi: 10.3389/fimmu.2024.1366841. eCollection 2024.
5
A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease.21号染色体三体相关的小胶质细胞造血基因变异赋予阿尔茨海默病人类诱导多能干细胞模型抗逆能力。
bioRxiv. 2024 Mar 14:2024.03.12.584646. doi: 10.1101/2024.03.12.584646.
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Mol Neurodegener. 2017 May 26;12(1):43. doi: 10.1186/s13024-017-0184-x.