用小胶质细胞移植来治疗阿尔茨海默病。
Replacing microglia to treat Alzheimer's disease.
机构信息
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
出版信息
Cell Stem Cell. 2023 Aug 3;30(8):1001-1003. doi: 10.1016/j.stem.2023.07.005.
Abstract
In this issue of Cell Stem Cell, Yoo et al. report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.
摘要
在本期《Cell Stem Cell》杂志中，Yoo 等人报道称，用源自系统移植造血细胞的 Trem2 野生型小胶质细胞样细胞替代 Trem2 敲除小胶质细胞，可纠正淀粉样变性小鼠模型中小胶质细胞功能障碍。这些发现强调了小胶质细胞替代疗法治疗阿尔茨海默病的潜力。
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