Intravoxel incoherent motion magnetic resonance imaging reconstruction from highly under-sampled diffusion-weighted PROPELLER acquisition data via physics-informed residual feedback unrolled network.

. The acquisition of diffusion-weighted images for intravoxel incoherent motion (IVIM) imaging is time consuming. This work aims to accelerate the scan through a highly under-sampling diffusion-weighted turbo spin echo PROPELLER (DW-TSE-PROPELLER) scheme and to develop a reconstruction method for accurate IVIM parameter mapping from the under-sampled data.The proposed under-sampling DW-TSE-PROPELLER scheme for IVIM imaging is that a few blades per-value are acquired and rotated along the-value dimension to cover high-frequency information. A physics-informed residual feedback unrolled network (PIRFU-Net) is proposed to directly estimate distortion-free and artifact-free IVIM parametric maps (i.e., the perfusion-free diffusion coefficientand the perfusion fraction) from highly under-sampled DW-TSE-PROPELLER data. PIRFU-Net used an unrolled convolution network to explore data redundancy in the k-q space to remove under-sampling artifacts. An empirical IVIM physical constraint was incorporated into the network to ensure that the signal evolution curves along the-value follow a bi-exponential decay. The residual between the realistic and estimated measurements was fed into the network to refine the parametric maps. Meanwhile, the use of synthetic training data eliminated the need for genuine DW-TSE-PROPELLER data.The experimental results show that the DW-TSE-PROPELLER acquisition was six times faster than full k-space coverage PROPELLER acquisition and within a clinically acceptable time. Compared with the state-of-the-art methods, the distortion-freeandmaps estimated by PIRFU-Net were more accurate and had better-preserved tissue boundaries on a simulated human brain and realistic phantom/rat brain/human brain data.Our proposed method greatly accelerates IVIM imaging. It is capable of directly and simultaneously reconstructing distortion-free, artifact-free, and accurateandmaps from six-fold under-sampled DW-TSE-PROPELLER data.