原发性乳腺癌和原发性卵巢癌发病风险因素：系统综述。
Risk factors for developing both primary breast and primary ovarian cancer: A systematic review.
机构信息
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA.
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA.
出版信息
Crit Rev Oncol Hematol. 2023 Oct;190:104081. doi: 10.1016/j.critrevonc.2023.104081. Epub 2023 Aug 2.
OBJECTIVE
Women with breast cancer have an increased risk of primary ovarian cancer (BR→OV), and women with ovarian cancer have an increased risk of primary breast cancer (OV→BR). This systematic review summarizes risk factors for developing BR→OV and OV→BR.
METHODS
We searched PubMed and Embase until June 2022.
RESULTS
We identified 23 articles meeting our inclusion criteria. Studies observed a lower risk of BR→OV for Black versus White women, alcohol consumption, radiotherapy and hormone therapy, BRCA2 versus BRCA1, and ER/PR positive versus negative breast tumors, and a higher risk with family history of breast/ovarian cancer, triple negative versus luminal breast cancer, and higher grade breast tumors. There was an increased risk of OV→BR with family history of cancer.
CONCLUSIONS
Tumor characteristics, and genetic and familial factors are associated with risk of BR→OV and OV→BR. These results could aid clinicians in decision-making for breast and ovarian cancer patients, including risk-reducing strategies.
目的
患有乳腺癌的女性发生原发性卵巢癌（BR→OV）的风险增加，而患有卵巢癌的女性发生原发性乳腺癌（OV→BR）的风险增加。本系统综述总结了发生 BR→OV 和 OV→BR 的风险因素。
方法
我们检索了 PubMed 和 Embase 数据库，检索时间截至 2022 年 6 月。
结果
我们确定了 23 篇符合纳入标准的研究。研究发现，与白人女性相比，黑人女性发生 BR→OV 的风险较低，而饮酒、放疗和激素治疗、BRCA2 与 BRCA1、ER/PR 阳性与阴性乳腺癌肿瘤与较低的风险相关，家族史有乳腺癌/卵巢癌、三阴性与 luminal 乳腺癌、以及更高分级的乳腺癌肿瘤与较高的风险相关。家族癌症史与 OV→BR 的风险增加相关。
结论
肿瘤特征、遗传和家族因素与 BR→OV 和 OV→BR 的风险相关。这些结果可以帮助临床医生为乳腺癌和卵巢癌患者做出决策，包括降低风险的策略。
Zotero 插件