Lao Jiahui, Wei Yifan, Liu Fanghua, Gong Tingting, Wu Qijun
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.
Center for Big Data Research in Health and Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Data Open Innovative Application Laboratory, Jinan, China.
Eur J Nutr. 2025 Mar 19;64(3):132. doi: 10.1007/s00394-025-03650-9.
Currently, there is controversy surrounding the association between dietary fatty acids (FAs) and ovarian cancer (OC) risk. We aimed to elucidate the aforementioned topic using data from a large cohort.
Women participating in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were included in this study. The dietary information of participants was collected through the diet history questionnaire. Multivariable Cox proportional hazards regression models incorporating restricted cubic splines were constructed to explore the association between dietary FAs intake and the incidence of OC.
Among 50,614 participants in the present study, a total of 277 cases of ovarian cancer were diagnosed. The median follow-up time was 9.44 years. Non-significant association between total FAs intake and risk of OC was observed (non-linear P = 0.060). Compared to the median of total FAs intake, hazard ratios were 1.68 (95% CI: 1.10-2.58) and 1.45 (95% CI: 1.05-1.99) for the 5th percentile and 10th percentile, respectively, while consuming more than the median failed to show significant findings. Similar results were found in the analyses of different types (saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids) and sources (animals and plants) of dietary FAs.
Inadequate consumption of various types and sources of dietary FAs might be associated with an increased risk of OC.
目前，饮食脂肪酸（FAs）与卵巢癌（OC）风险之间的关联存在争议。我们旨在利用来自大型队列的数据阐明上述主题。
本研究纳入了参与前列腺、肺、结肠和卵巢癌筛查试验的女性。通过饮食史问卷收集参与者的饮食信息。构建包含受限立方样条的多变量Cox比例风险回归模型，以探讨饮食脂肪酸摄入量与卵巢癌发病率之间的关联。
在本研究的50614名参与者中，共诊断出277例卵巢癌病例。中位随访时间为9.44年。观察到总脂肪酸摄入量与卵巢癌风险之间无显著关联（非线性P = 0.060）。与总脂肪酸摄入量的中位数相比，第5百分位数和第10百分位数的风险比分别为1.68（95%CI：1.10 - 2.58）和1.45（95%CI：1.05 - 1.99），而摄入量超过中位数时未显示出显著结果。在对不同类型（饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸）和来源（动物和植物）的饮食脂肪酸分析中也发现了类似结果。
各种类型和来源的饮食脂肪酸摄入不足可能与卵巢癌风险增加有关。
