Guttery David S, Zeeshan Mohammad, Holder Anthony A, Tromer Eelco C, Tewari Rita
School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK; Department of Genetics and Genome Biology, College of Life Sciences, University of Leicester, Leicester, UK.
School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Trends Parasitol. 2023 Oct;39(10):812-821. doi: 10.1016/j.pt.2023.07.002. Epub 2023 Aug 2.
Meiosis is sexual cell division, a process in eukaryotes whereby haploid gametes are produced. Compared to canonical model eukaryotes, meiosis in apicomplexan parasites appears to diverge from the process with respect to the molecular mechanisms involved; the biology of Plasmodium meiosis, and its regulation by means of post-translational modification, are largely unexplored. Here, we discuss the impact of technological advances in cell biology, evolutionary bioinformatics, and genome-wide functional studies on our understanding of meiosis in the Apicomplexa. These parasites, including Plasmodium falciparum, Toxoplasma gondii, and Eimeria spp., have significant socioeconomic impact on human and animal health. Understanding this key stage during the parasite's life cycle may well reveal attractive targets for therapeutic intervention.
减数分裂是有性细胞分裂，这是真核生物中产生单倍体配子的过程。与典型的模式真核生物相比，顶复门寄生虫的减数分裂在涉及的分子机制方面似乎与该过程有所不同；疟原虫减数分裂的生物学及其通过翻译后修饰的调控在很大程度上尚未得到探索。在这里，我们讨论细胞生物学、进化生物信息学和全基因组功能研究方面的技术进步对我们理解顶复门减数分裂的影响。这些寄生虫，包括恶性疟原虫、弓形虫和艾美耳属物种，对人类和动物健康具有重大的社会经济影响。了解寄生虫生命周期中的这一关键阶段很可能会揭示出有吸引力的治疗干预靶点。
