倍他米松对猪血浆和肠钙结合蛋白以及25-羟维生素D3代谢的影响。

The effects of betamethasone on plasma and intestinal calcium binding protein and on 25-hydroxyvitamin D3 metabolism in the pig.

作者信息

Maunder E M, Sommerville B A, Pillay A V, Ross R, Marshall D, Care A D

出版信息

Comp Biochem Physiol B. 1986;83(3):653-7. doi: 10.1016/0305-0491(86)90313-5.

Abstract

Betamethasone (50 micrograms/kg body weight/day) given to young pigs reduced calcium absorption, growth and plasma vitamin D dependent calcium binding protein (CaBP) concentration. No changes occurred in plasma 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and intestinal CaBP concentrations. 1,25(OH)2D3 (0.1 microgram/kg body weight/day) given with betamethasone increased calcium absorption although growth and plasma CaBP concentrations remained low. Intestinal CaBP levels remained unchanged. Plasma CaBP concentrations were not consistently related to intestinal CaBP or calcium absorption in the presence of betamethasone. We conclude that betamethasone-induced depression of calcium absorption was not mediated by alterations in intestinal CaBP, but the mechanism remains obscure.

摘要

给幼猪注射倍他米松（50微克/千克体重/天）会降低钙吸收、生长速度以及血浆中维生素D依赖性钙结合蛋白（CaBP）的浓度。血浆1,25-二羟维生素D3（1,25(OH)2D3）和肠道CaBP浓度未发生变化。与倍他米松一起注射1,25(OH)2D3（0.1微克/千克体重/天）可增加钙吸收，尽管生长速度和血浆CaBP浓度仍较低。肠道CaBP水平保持不变。在倍他米松存在的情况下，血浆CaBP浓度与肠道CaBP或钙吸收之间没有始终如一的关联。我们得出结论，倍他米松引起的钙吸收抑制不是由肠道CaBP的改变介导的，但其机制仍不清楚。