Orthopaedic Biomechanics Lab, Victoria Hospital, London, ON N6A-5W9, Canada.
Orthopaedic Biomechanics Lab, Victoria Hospital, Room A6-144, 800 Commissioners Road East, London, ON N6A-5W9, Canada.
J Biomech Eng. 2023 Dec 1;145(12). doi: 10.1115/1.4063123.
Biomechanical engineers and physicists commonly employ biological bone for biomechanics studies, since they are good representations of living bone. Yet, there are challenges to using biological bone, such as cost, degradation, disease, ethics, shipping, sourcing, storage, variability, etc. Therefore, the Synbone® company has developed a series of synthetic bones that have been used by biomechanical investigators to offset some drawbacks of biological bone. There have been a number of published biomechanical reports using these bone surrogates for dental, injury, orthopedic, and other applications. But, there is no prior review paper that has summarized the mechanical properties of these synthetic bones in order to understand their general performance or how well they represent biological bone. Thus, the goal of this article was to survey the English-language literature on the mechanical properties of these synthetic bones. Studies were included if they quantitatively (a) characterized previously unknown values for synthetic bone, (b) validated synthetic versus biological bone, and/or (c) optimized synthetic bone performance by varying geometric or material parameters. This review of data, pros, cons, and future work will hopefully assist biomechanical engineers and physicists that use these synthetic bones as they develop experimental testing regimes and computational models.
生物力学工程师和物理学家通常将生物骨骼用于生物力学研究，因为它们是活体骨骼的良好代表。然而，使用生物骨骼存在一些挑战，例如成本、降解、疾病、伦理、运输、来源、储存、可变性等。因此，Synbone®公司开发了一系列合成骨骼，已被生物力学研究人员用于克服生物骨骼的一些缺点。已经有许多关于使用这些骨骼替代品进行牙科、损伤、矫形等应用的生物力学报告。但是，没有之前的综述论文总结了这些合成骨骼的机械性能，以了解它们的一般性能或它们在多大程度上代表了生物骨骼。因此，本文的目的是调查关于这些合成骨骼机械性能的英文文献。如果研究定量地（a）描述了合成骨骼的未知值，（b）验证了合成骨骼与生物骨骼的差异，和/或（c）通过改变几何或材料参数来优化合成骨骼的性能，则将其纳入研究。对数据、优缺点和未来工作的回顾将有助于使用这些合成骨骼的生物力学工程师和物理学家，因为他们正在开发实验测试方案和计算模型。
