内脏神经切断术可消除大鼠肾上腺中神经肽Y样免疫反应性随年龄增长的增加。

Splanchnic nerve transection abolishes the age-dependent increase of neuropeptide Y-like immunoreactivity in rat adrenal gland.

作者信息

Higuchi H, Yang H Y

出版信息

J Neurochem. 1986 May;46(5):1658-60. doi: 10.1111/j.1471-4159.1986.tb01792.x.

DOI:10.1111/j.1471-4159.1986.tb01792.x

Abstract

Using an antiserum directed against porcine neuropeptide Y (NPY), a high concentration of NPY immunoreactivity (NPY-IR) was detected in rat adrenal gland. The level of NPY-IR in the adrenal gland was found to increase considerably with age. Biochemical characterization by reverse-phase HPLC indicated that this increase was due to accumulations of NPY and another molecular form of NPY-like immunoreactive peptide. Chronic denervation of the splanchnic nerve abolished this age-dependent increase of NPY-IR rat adrenal gland.

摘要

使用针对猪神经肽Y（NPY）的抗血清，在大鼠肾上腺中检测到高浓度的NPY免疫反应性（NPY-IR）。发现肾上腺中NPY-IR的水平随年龄显著增加。反相高效液相色谱法的生化特性表明，这种增加是由于NPY和另一种NPY样免疫反应性肽分子形式的积累。内脏神经的慢性去神经支配消除了大鼠肾上腺中这种依赖年龄的NPY-IR增加。