一种聚集诱导发光荧光探针，用于活细胞中 Hg 的高灵敏和选择性检测和成像。
An aggregation-induced emission fluorescent probe for highly sensitive and selective detection and imaging of Hg in living cells.
机构信息
Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metal Pollution in the Upper Reaches of Xiangjiang River, College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421001, PR China.
Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metal Pollution in the Upper Reaches of Xiangjiang River, College of Chemistry and Material Science, Hengyang Normal University, Hengyang 421001, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Dec 15;303:123209. doi: 10.1016/j.saa.2023.123209. Epub 2023 Jul 26.
Mercury ions (Hg), as one of heavy transition metals (HTM), is a highly toxic metal that is hazardous to human health. Here an aggregation-induced emission (AIE) fluorescent probe is designed for the highly sensitive and selective detection of Hg. The probe is engineered with a tetraphenylethene (TPE) derivative as the fluorophore and thiopropionic acid as the site of recognition for Hg. Due to the different solubilities of the probe AIE-COOH and its corresponding product after reaction with Hg. The probe demonstrates a maximum detection limit of 22 nM and a fast response time of ∼100 s. Simultaneously, AIE-COOH exhibits outstanding detectivity and hypersensitivity for the detection of Hg in aqueous solutions. These characteristics demonstrate that AIE-COOH hold a great potential in environmental, food and biological systems. Moreover, we have also successfully applied it to Hg fluorescence imaging in in living cells.
汞离子（Hg）作为一种重金属过渡元素（HTM），是一种对人类健康危害极大的高毒性金属。在这里，设计了一种聚集诱导发射（AIE）荧光探针，用于对 Hg 进行高灵敏度和选择性检测。该探针以四苯乙烯（TPE）衍生物为荧光团，以巯基丙酸为 Hg 的识别位点。由于探针 AIE-COOH 及其与 Hg 反应后的相应产物的溶解度不同。探针的最大检测限为 22 nM，响应时间约为 100 s。同时，AIE-COOH 在水溶液中对 Hg 的检测具有出色的检测能力和超敏性。这些特性表明 AIE-COOH 在环境、食品和生物系统中具有巨大的应用潜力。此外，我们还成功地将其应用于活细胞中的 Hg 荧光成像。
Zotero 插件