Recent advances in metal-organic frameworks: Synthesis, application and toxicity.

Metal-organic frameworks (MOFs) are a new class of crystalline porous hybrid materials with high porosity, large specific surface area and adjustable channel structure and biocompatibility, which are being investigated with increasing interest for energy storage and conversion, gas adsorption/separation, catalysis, sensing and biomedicine. However, the practical applications of MOFs make them release into the environment inevitable, posing a threat to humans and organisms. In this article, we cover advances in the currently available MOFs synthesis methods and the emerging applications of MOFs, especially in the biomedical field (therapeutic agents and bioimaging). Additionally, after evaluating the current status of main exposure routes and affecting factors in the field of MOFs-toxicity, the molecular mechanism is also clarified and identified. Knowledge gaps are identified from such a summarization and frontier development are explored for MOFs. Afterwards, we also present the limitations, challenges, and future perspectives in the study of the entire life cycle of MOFs. This review emphasizes the need for a more targeted discussion of the latest, widely used and effective versatile material class in order to exploit the full potential of high-performance and non-toxicity MOFs in the future.