抗3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）免疫介导的坏死性肌病中肌营养不良蛋白表达降低及靶向肌营养不良蛋白的微小RNA升高。 - Suppr

Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy.

作者信息

Marmen Maude B, Orfi Zakaria, Dort Junio, Proulx-Gauthier Jean-Philippe, Chrestian Nicolas, Dumont Nicolas A, Ellezam Benjamin

机构信息

Division of Rheumatology, CHU de Québec-Université Laval, Québec, Québec, Canada.

CHU Sainte-Justine Research Centre, Montréal, Québec, Canada.

出版信息

Acta Neuropathol. 2023 Oct;146(4):655-658. doi: 10.1007/s00401-023-02619-4. Epub 2023 Aug 5.

DOI:10.1007/s00401-023-02619-4

PMID:37543531

Abstract

摘要

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Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy.抗3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）免疫介导的坏死性肌病中肌营养不良蛋白表达降低及靶向肌营养不良蛋白的微小RNA升高。

Acta Neuropathol. 2023 Oct;146(4):655-658. doi: 10.1007/s00401-023-02619-4. Epub 2023 Aug 5.

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Immune-mediated myopathy related to anti 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies as an emerging cause of necrotizing myopathy induced by statins.免疫介导的肌病与抗 3-羟基-3-甲基戊二酰辅酶 A 还原酶抗体有关，是他汀类药物引起的坏死性肌病的一个新出现的原因。

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Immune-Mediated Necrotizing Myopathy.免疫介导性坏死性肌病。

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The pathogenesis of anti-signal recognition particle necrotizing myopathy: A Review.抗信号识别颗粒坏死性肌病的发病机制：综述。

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Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.cGAS-STING 通路的激活 - 皮肌炎和免疫介导性坏死性肌病中肌纤维萎缩/坏死的可能原因。

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Arthritis Rheumatol. 2020 Jul;72(7):1170-1183. doi: 10.1002/art.41215. Epub 2020 May 31.

Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients.他汀类药物引起的抗 HMGCR 肌病：55 例患者无皮质类固醇缓解的成功治疗策略。

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Anti-HMGCR Myopathy.抗 HMGCR 肌病。

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Neuromuscul Disord. 2018 Jan;28(1):87-99. doi: 10.1016/j.nmd.2017.09.016. Epub 2017 Oct 23.

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Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy.

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