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Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy.

作者信息

Marmen Maude B, Orfi Zakaria, Dort Junio, Proulx-Gauthier Jean-Philippe, Chrestian Nicolas, Dumont Nicolas A, Ellezam Benjamin

机构信息

Division of Rheumatology, CHU de Québec-Université Laval, Québec, Québec, Canada.

CHU Sainte-Justine Research Centre, Montréal, Québec, Canada.

出版信息

Acta Neuropathol. 2023 Oct;146(4):655-658. doi: 10.1007/s00401-023-02619-4. Epub 2023 Aug 5.

DOI:10.1007/s00401-023-02619-4
PMID:37543531
Abstract
摘要

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2
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.cGAS-STING 通路的激活 - 皮肌炎和免疫介导性坏死性肌病中肌纤维萎缩/坏死的可能原因。
J Clin Lab Anal. 2022 Oct;36(10):e24631. doi: 10.1002/jcla.24631. Epub 2022 Aug 28.
3
Muscle Weakness in Myositis: MicroRNA-Mediated Dystrophin Reduction in a Myositis Mouse Model and Human Muscle Biopsies.
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4
Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients.他汀类药物引起的抗 HMGCR 肌病：55 例患者无皮质类固醇缓解的成功治疗策略。
Arthritis Res Ther. 2020 Jan 8;22(1):5. doi: 10.1186/s13075-019-2093-6.
5
Anti-HMGCR Myopathy.抗 HMGCR 肌病。
J Neuromuscul Dis. 2018;5(1):11-20. doi: 10.3233/JND-170282.
6
224th ENMC International Workshop:: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016.第224届ENMC国际研讨会：免疫介导性坏死性肌病的临床-血清学-病理学分类，荷兰赞德福特，2016年10月14日至16日。
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